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An individual-specific understanding of how synchrony becomes curative: study protocol
Sigal Zilcha-Mano1, Yael Bouknik2, Michal Malka2
1Department of Psychology, University of Haifa, Mount Carmel, Haifa, 31905, Israel. sigalzil@gmail.com.
BMC Psychiatry
|June 6, 2025
Summary
This study introduces individual-specific synchrony signatures to understand how interpersonal synchrony impacts mental health. Tailored adjustments to these signatures may enhance therapeutic change for conditions like major depressive disorder.
Area of Science:
- Psychology
- Clinical Psychology
- Interpersonal Dynamics
Background:
- Interpersonal interactions significantly influence mental health, yet the underlying mechanisms are not fully understood.
- Existing research often assumes higher synchrony is universally beneficial, overlooking individual differences.
Purpose of the Study:
- To systematically test the novel concept of an individual-specific synchrony signature.
- To investigate if tailored synchrony adjustments, based on individual signatures, can facilitate therapeutic change.
Main Methods:
- Study 1 utilized the Synchrony Interaction Paradigm to identify individual synchrony signatures in 68 participants, including those with major depressive disorder (MDD).
- Study 2 employed a randomized controlled trial with 78 MDD patients to assess if tailored signature adjustments promote therapeutic change.
- Multimodal markers (motion, acoustic, physiological, hormonal, facial expressions) were used to differentiate stable synchrony traits from real-time interaction deviations.
Main Results:
- The existence and characteristics of individual-specific synchrony signatures were investigated.
- The research aims to demonstrate how personalized synchrony adjustments can lead to therapeutic improvements in MDD patients.
Conclusions:
- This research redefines synchrony as an individual-specific mechanism for change, highlighting its multimodal nature.
- Findings advance a personalized framework for understanding synchrony's impact on mental health and inform targeted therapeutic interventions.

