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Updated: Sep 19, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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Impact of Renal Function and Acute Kidney Injury on Long-term Outcomes After Percutaneous Coronary Intervention

Vinayak Nagaraja1, Charanjit S Rihal1, Guy Reeder1

  • 1Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN.

Mayo Clinic Proceedings
|June 7, 2025
PubMed

Insights

Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) affects 9.3% of patients, with higher mortality and adverse cardiac events. Risk factors include older age, diabetes, heart failure, and chronic kidney disease.

Area of Science:

  • Cardiology
  • Nephrology
  • Interventional Cardiology

Background:

  • Acute kidney injury (AKI) is a significant complication following percutaneous coronary intervention (PCI).
  • Understanding the incidence, predictors, and outcomes of AKI post-PCI is crucial for patient management.

Purpose of the Study:

  • To determine the incidence of AKI after PCI.
  • To identify predictors associated with AKI development.
  • To evaluate the prognostic implications of AKI on mortality and adverse cardiovascular events.

Main Methods:

  • Retrospective analysis of 9199 patients undergoing PCI from January 2009 to June 2023.
  • AKI defined as an increase in serum creatinine by ≥0.3 mg/dL or ≥1.5 times baseline.
  • Multivariable analysis used to identify predictors and assess mortality risk.

Main Results:

  • The incidence of AKI was 9.3% (856 patients), with a monotonic yearly increase observed.
  • Key predictors included older age, female sex, diabetes, congestive heart failure, chronic kidney disease, acute myocardial infarction, intra-aortic balloon pump use, and contrast volume.
  • AKI was strongly associated with increased in-hospital mortality (11.1% vs 1.0%) and higher long-term adverse cardiovascular event rates.

Conclusions:

  • The incidence of AKI following PCI remains high in the current era.
  • AKI significantly increases in-hospital and long-term mortality risks.
  • Patients developing AKI post-PCI experience worse long-term outcomes, including higher rates of adverse cardiac events.
Abstract

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