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Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

425
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Related Experiment Video

Updated: Sep 19, 2025

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

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Quantified motility assessment in paediatric inflammatory bowel disease: a multi-reader study.

Riwa Meshaka1, Heather E Fitzke2, Joy Barber3

  • 1Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3BH, UK. riwa.meshaka@gosh.nhs.uk.

Pediatric Radiology
|June 7, 2025
PubMed
Summary

Quantified bowel motility using magnetic resonance enterography (MRE) in pediatric inflammatory bowel disease shows good agreement among readers with varied experience, supporting its use as a biomarker.

Keywords:
Crohn diseaseGastrointestinal motilityInflammatory bowel diseasesMagnetic resonance imaging (cine)Paediatrics

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Last Updated: Sep 19, 2025

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Area of Science:

  • Gastroenterology
  • Medical Imaging
  • Pediatric Inflammatory Bowel Disease

Background:

  • Quantitative bowel motility via magnetic resonance enterography (MRE) shows potential as an inflammatory bowel disease (IBD) biomarker.
  • Experienced readers have demonstrated its utility in research settings.

Purpose of the Study:

  • To evaluate the agreement among non-experienced readers for quantified bowel motility measurements.
  • To assess the reliability of MRE-derived motility metrics in pediatric IBD.

Main Methods:

  • Retrospective analysis of MREs from pediatric IBD patients (<18 years).
  • Quantified motility software used to analyze cine images from two MREs.
  • Inter-reader agreement assessed using Bland-Altman analysis and percentage agreement for motility index changes.

Main Results:

  • Fair to excellent agreement in the direction of motility change was observed.
  • Junior readers agreed with experienced readers on motility change direction 73-84% of the time.
  • Senior readers showed 67-85% agreement with experienced readers, with acceptable limits of agreement for motility index change.

Conclusions:

  • Quantified bowel motility measurements in pediatric IBD are reliable across readers with varying experience levels.
  • This supports the potential of MRE-based motility assessment as a reproducible biomarker in pediatric IBD management.