Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.1K
Spermatogenesis01:41

Spermatogenesis

102.2K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.2K
  1. Home
  3. Increased Susceptibility To Prostate Cancer Biomarkers In The Offspring Of Male Mouse Progenitors With Lifelong Or Early Life Exposure To High-fat Diet.
  1. Home
  3. Increased Susceptibility To Prostate Cancer Biomarkers In The Offspring Of Male Mouse Progenitors With Lifelong Or Early Life Exposure To High-fat Diet.

Related Experiment Video

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

517

Increased susceptibility to prostate cancer biomarkers in the offspring of male mouse progenitors with lifelong or

Mariana Santos-Pereira1,2,3, Sara C Pereira2,3,4, Bárbara Matos1

  • 1Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, 3810-193, Portugal.

European Journal of Nutrition
|June 7, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
EpigeneticObesityProstate cancerTransgenerational

More Related Videos

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

531
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

29.6K

Related Experiment Videos

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

517
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

531
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

29.6K

Paternal obesity via high-fat diet (HFD) may impact offspring prostate cancer (PCa) risk. Studies show HFD affects PCa biomarkers like HOXB13 and AR, suggesting intergenerational effects.

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Obesity is linked to hormonal imbalance, inflammation, and oxidative stress, contributing to prostate cancer (PCa) development.
  • Epigenetic changes from obesity may be transmitted across generations, potentially influencing PCa susceptibility in offspring.

Purpose of the Study:

  • To investigate the impact of paternal high-fat diet (HFD) exposure on PCa biomarkers (HOXB13, AR) in offspring.
  • To explore correlations between obesity markers and PCa biomarkers across generations.
  • To assess transgenerational effects of paternal diet on PCa risk factors.

Main Methods:

  • A transgenerational mouse model (Mus musculus) exposed F0 males to standard chow, lifelong HFD, or transient HFD (HFDt).
  • Prostate tissues analyzed for AR, HOXB13, FTO, and TNF-α expression, promoter methylation, protein nitration, and lipid peroxidation.
  • Evaluated PCa biomarkers and obesity markers in F0, F1, and F2 generations.

    • Main Results:

    • AR expression was unchanged, but HOXB13, FTO, and TNF-α decreased in F1 HFDt offspring.
    • Positive correlations observed between HOXB13 and AR, and between FTO, TNF-α, and PCa biomarkers.
    • Lipid peroxidation increased in F0 HFD but decreased in F1/F2 HFD and HFDt offspring.

    Conclusions:

    • Paternal HFD exposure influences PCa biomarkers in offspring, indicating intergenerational effects.
    • Obesity-related factors and PCa biomarkers are interconnected across generations.
    • Offspring of fathers with HFD exposure may have an increased risk for elevated PCa biomarkers.