Secondary metabolites from Pometia pinnata leaves

A new hederagenin glycoside, named pometin B [3-O-(5'''-O-acetyl-α-L-arabinofuranosyl)-(1'''→3')-[α-L-rhamnopyranosyl-(1''→2')]-β-L-arabinopyranosyl hederagenin] (1), was isolated from Pometia pinnata leaves along with known compounds, including stigmasterol-3-O-α-glucoside (2), kaempferol-3-O-α-rhamnoside (3), quercetin-3-O-α-rhamnoside (4), and proanthocyanidin A2 (5). The chemical structures of these compounds were confirmed through detailed analysis of 1D and 2D NMR spectra, supported by mass spectrometry data. The identities of known compounds were further verified by comparison with the corresponding data in the literature. Compound 1 exhibited notable cytotoxic activity against the MCF7 cell line with the IC₅₀ value of 3.69 μg/mL. Compounds 3-5 showed significant antioxidant and alpha-glucosidase inhibitory activities.