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Related Experiment Videos

The compression of granulates containing solid dispersions.

R Kinget, R Kemel

    Die Pharmazie
    |July 1, 1985
    PubMed
    Summary

    Polyethylene glycol (PEG 6000) creates optimal diazepam solid dispersion tablets. Adding a strong disintegrant extragranularly improves tablet disintegration, maintaining physical integrity under varying humidity.

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    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Solid dispersions enhance drug solubility and bioavailability.
    • Diazepam is a widely used anxiolytic and anticonvulsant medication.

    Purpose of the Study:

    • To develop and optimize diazepam tablets using solid dispersion technology.
    • To evaluate the impact of polyethylene glycol (PEG 6000) and disintegrants on tablet properties.

    Main Methods:

    • Preparation of granulates containing diazepam solid dispersions with PEG 6000.
    • Compression of granulates into tablets.
    • Evaluation of tablet disintegration and physical properties.
    • Assessment of tablet stability under different humidity conditions.

    Main Results:

    • Tablets formulated with PEG 6000 exhibited superior physical properties.
    • Extragranular addition of a strong disintegrant was crucial for effective tablet disintegration.
    • The optimized tablets maintained their physical integrity when stored in normal or low humidity environments.

    Conclusions:

    • Polyethylene glycol (PEG 6000) is an effective carrier for diazepam solid dispersions in tablet formulations.
    • The combination of PEG 6000 and extragranular disintegrants yields robust and rapidly disintegrating diazepam tablets.
    • The developed tablet formulation demonstrates good stability, suitable for pharmaceutical applications.

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