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  3. Are Anxious Mondays Associated With Hpa-axis Dysregulation? A Longitudinal Study Of Older Adults In England
  1. Home
  3. Are Anxious Mondays Associated With Hpa-axis Dysregulation? A Longitudinal Study Of Older Adults In England

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Are anxious Mondays associated with HPA-axis dysregulation? A longitudinal study of older adults in England

Tarani Chandola1, Wanying Ling2, Patrick Rouxel3

  • 1Department of Sociology, The University of Hong Kong, Hong Kong; Social Science Research Centre, The University of Hong Kong, Hong Kong; Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.

Journal of Affective Disorders
|June 7, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Older adults experiencing anxiety on Mondays show significantly higher HPA-axis dysregulation, indicated by elevated hair cortisol levels. This Monday anxiety effect on the hypothalamic-pituitary-adrenal axis is evident regardless of employment status.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Psychoneuroimmunology

Background:

  • The hypothalamic-pituitary-adrenal (HPA) axis regulates stress response.
  • Dysregulation of the HPA axis is linked to various health issues.
  • The impact of weekly cycles on HPA axis function in older adults requires further investigation.

Purpose of the Study:

  • To determine if the association between perceived anxiety and HPA-axis dysregulation is more pronounced on Mondays compared to other days of the week.
  • To investigate the relationship between Monday anxiety and subsequent HPA-axis markers in older adults.

Main Methods:

  • An observational study utilizing longitudinal data from 3511 older adults (aged 50+) in England.
  • Data collected from wave 6 of the English Longitudinal Study of Ageing (2012-2013).
  • Measured hair cortisol levels and total glucocorticoid production as indicators of HPA-axis activity.

    • Main Results:

    • Strong evidence found for an association between reporting anxiety on Mondays and HPA-axis dysregulation.
    • Older adults feeling anxious on Mondays had 23% higher hair cortisol levels (measured up to 2 months later) compared to those anxious on other days.
    • No significant differences in cortisol or glucocorticoid production were found for anxiety on other weekdays.
    • The Monday anxiety association with HPA-axis dysregulation persisted in both working and nonworking individuals.

    Conclusions:

    • HPA-axis dysregulation is significantly pronounced in older adults who report anxiety specifically on Mondays.
    • This Monday-associated HPA-axis dysregulation is observed irrespective of employment status.
    • Both working and nonworking older adults are susceptible to HPA-axis dysregulation linked to the start of the week.