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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Updated: Sep 19, 2025

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Melatonin: a potential target for regulating ovarian function.

Jiahui He1, Tiantian Ye2, Keyi Xu2

  • 1Zhuji People's Hospital of Zhejiang Province, Shaoxing, Zhuji, China.

Archives of Gynecology and Obstetrics
|June 8, 2025
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Summary
This summary is machine-generated.

Melatonin (MT) protects ovarian function by combating oxidative stress and improving oocyte quality. This review highlights MT

Keywords:
MelatoninOvarian functionOxidative stress

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Area of Science:

  • Reproductive biology
  • Endocrinology
  • Cellular physiology

Background:

  • Ovarian dysfunction manifests as decreased oocyte quality and follicle count.
  • Environmental factors, toxins, and lifestyle choices negatively impact ovarian function.
  • Melatonin (MT) is an endogenous antioxidant hormone with protective effects on reproductive cells.

Purpose of the Study:

  • To review the multifaceted role of melatonin in regulating ovarian function.
  • To elucidate the mechanisms by which melatonin mitigates ovarian aging and dysfunction.
  • To explore melatonin's therapeutic potential in clinical settings.

Main Methods:

  • Literature review of existing studies on melatonin and ovarian function.
  • Analysis of melatonin synthesis, secretion, and local ovarian actions.
  • Examination of melatonin's protective effects against various ovarian injury factors.

Main Results:

  • Melatonin demonstrates significant antioxidant and free radical scavenging properties.
  • MT enhances oocyte maturation, fertilization, and embryonic development.
  • Melatonin alleviates ovarian decline caused by diverse detrimental factors.

Conclusions:

  • Melatonin plays a crucial role in maintaining ovarian function and delaying aging.
  • Understanding melatonin's mechanisms provides a basis for clinical interventions.
  • Further research into melatonin's therapeutic applications in reproductive health is warranted.