Related Experiment Video

Updated: Sep 19, 2025

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.0K

Melatonin: a potential target for regulating ovarian function

Jiahui He1, Tiantian Ye2, Keyi Xu2

  • 1Zhuji People's Hospital of Zhejiang Province, Shaoxing, Zhuji, China.

Archives of Gynecology and Obstetrics
|June 8, 2025
PubMed
Abstract

Insights

Melatonin (MT) protects ovarian function by combating oxidative stress and improving oocyte quality. This review highlights MT

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Cellular physiology

Background:

  • Ovarian dysfunction manifests as decreased oocyte quality and follicle count.
  • Environmental factors, toxins, and lifestyle choices negatively impact ovarian function.
  • Melatonin (MT) is an endogenous antioxidant hormone with protective effects on reproductive cells.

Purpose of the Study:

  • To review the multifaceted role of melatonin in regulating ovarian function.
  • To elucidate the mechanisms by which melatonin mitigates ovarian aging and dysfunction.
  • To explore melatonin's therapeutic potential in clinical settings.

Main Methods:

  • Literature review of existing studies on melatonin and ovarian function.
  • Analysis of melatonin synthesis, secretion, and local ovarian actions.
  • Examination of melatonin's protective effects against various ovarian injury factors.

Main Results:

  • Melatonin demonstrates significant antioxidant and free radical scavenging properties.
  • MT enhances oocyte maturation, fertilization, and embryonic development.
  • Melatonin alleviates ovarian decline caused by diverse detrimental factors.

Conclusions:

  • Melatonin plays a crucial role in maintaining ovarian function and delaying aging.
  • Understanding melatonin's mechanisms provides a basis for clinical interventions.
  • Further research into melatonin's therapeutic applications in reproductive health is warranted.
Keywords:
MelatoninOvarian functionOxidative stress

More Related Videos

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.6K
Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay08:00

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay

Published on: June 16, 2021

4.5K

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
328
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
3.5K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
729
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
269
The Pineal Gland01:02

The Pineal Gland

The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
2.6K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
249