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Pan-immune-inflammatory value in patients with hyperuricemia: a population-based study.

Qian Zhang1, Lin Li1, Jing Zhou1

  • 1Department of Endocrinology, Rheumatology and Immunology, PLA Rocket Force Characteristic Medical Center, Beijing, 100088, China.

Clinical Rheumatology
|June 8, 2025
PubMed
Summary

The pan-immune-inflammation value (PIV) is linked to a higher prevalence and risk of hyperuricemia. Elevated PIV also increases the risk of all-cause and cardiovascular mortality in individuals with hyperuricemia.

Keywords:
HyperuricemiaMortalityNHANESPan-immune-inflammation valuePopulation-based study

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Area of Science:

  • Biomarkers and Public Health

Background:

  • Systemic inflammation is implicated in various chronic diseases.
  • The pan-immune-inflammation value (PIV) is an emerging biomarker reflecting systemic inflammation.
  • Hyperuricemia is a condition associated with increased cardiovascular risk.

Purpose of the Study:

  • To investigate the association between PIV and hyperuricemia prevalence in US adults.
  • To examine the relationship between PIV and the risk of hyperuricemia.
  • To assess the impact of PIV on all-cause and cardiovascular mortality in hyperuricemic individuals.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018.
  • Calculated PIV using neutrophil, platelet, monocyte, and lymphocyte counts.
  • Defined hyperuricemia based on established uric acid level thresholds for males and females.

Main Results:

  • A total of 31,151 participants were analyzed.
  • Hyperuricemia prevalence increased with higher PIV levels (P < 0.001).
  • Higher PIV quartiles were associated with an increased risk of hyperuricemia (OR = 1.19, P = 0.001), showing a dose-response relationship.
  • Elevated PIV correlated with increased all-cause and cardiovascular mortality in hyperuricemic patients (P < 0.001).

Conclusions:

  • PIV is a potential epidemiological tool for assessing immune-inflammatory responses.
  • PIV may aid in evaluating hyperuricemia risk and its prognostic implications.
  • The study highlights PIV's role in understanding hyperuricemia and associated mortality risks.