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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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  5. Biomedical And Clinical Sciences
  7. Immunology
  9. Applied Immunology (incl. Antibody Engineering, Xenotransplantation And T-cell Therapies)
  11. Serpina1 Is A New Frontier In Cancer Immunotherapy And Drug Targeting By Pan-cancer Analysis

SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis

Chen Fu1, Yanyun Hu2,3,4, Lei Yang5

  • 1Pharmaceutical Sciences Laboratory Center, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.

Discover Oncology
|June 8, 2025

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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

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View abstract on PubMed

Summary
This summary is machine-generated.

SERPINA1, an autophagy-related protein, shows abnormal expression in many tumors, impacting prognosis. Targeting SERPINA1 may offer new avenues for cancer immunotherapy and drug therapies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Autophagy modulates immune responses and tumor growth.
  • SERPINA1 is an autophagy-related protein and serine protease inhibitor with therapeutic potential.

Purpose of the Study:

  • To investigate the role of SERPINA1 in various cancers.
  • To explore SERPINA1 as a potential target for immunotherapy and drug therapy.

Main Methods:

  • Multi-omic database analysis of SERPINA1 expression, prognosis, methylation, mutation, and signaling pathways.
  • Analysis of SERPINA1's relationship with immune cells and drug sensitivity.
  • Single-cell sequencing for validation in different cancer types.

Main Results:

  • Abnormal SERPINA1 expression correlates with poor prognosis in many tumors.
Keywords:
Immune checkpointsImmune microenvironmentImmunotherapyPan-cancer

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  • SERPINA1 expression is linked to DNA methylation, mutations, and post-translational modifications in breast cancer.
  • SERPINA1 positively correlates with macrophages, promoting M2 polarization, and is found in glioma immune microenvironments.

    • Conclusions:

    • SERPINA1 plays a role in cancer progression.
    • SERPINA1 represents a promising new target for cancer immunotherapy and drug development.
    SERPINA1