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Updated: Sep 19, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Targeting to high density lipoprotein cholesterol: new insights for inflammatory bowel disease treatment
Xiaotong Wang1, Xuefei Li1, Kezhen Liu2
1Department of Gastroenterology, Xiangya Hospital, Central South University Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China.
Insights
High-density lipoprotein cholesterol (HDL-C) is reduced in inflammatory bowel disease (IBD) and linked to inflammation. Therapies increasing HDL-C, like cholesteryl ester transfer protein inhibitors (CETPi), show promise for IBD treatment.
Area of Science:
- Biochemistry
- Immunology
- Gastroenterology
Background:
- High-density lipoprotein cholesterol (HDL-C) is recognized for its anti-inflammatory and vasoprotective roles, particularly in cardiovascular disease and sepsis.
- Its potential role in inflammatory bowel disease (IBD) has not been extensively studied.
Purpose of the Study:
- To investigate the link between HDL-C metabolism and IBD.
- To explore the therapeutic potential of targeting HDL-C for IBD prevention and treatment.
Main Methods:
- Analysis of serum lipid levels and IBD clinical manifestations in prospective and retrospective cohorts.
- In vivo experiments to evaluate the therapeutic effects and mechanisms of cholesteryl ester transfer protein inhibitors (CETPis) in experimental colitis.
Main Results:
- IBD patients exhibited significantly lower HDL-C levels, negatively correlated with inflammatory status.
- Biologics agents increased HDL-C levels; pretreatment HDL-C concentration predicted disease severity.
- CETPi administration, before or after colitis onset, reduced disease severity.
- Elevated HDL-C was associated with ATF3-dependent macrophage anti-inflammatory reprogramming and improved gut barrier function.
Conclusions:
- HDL-C plays a significant role in IBD pathogenesis and progression.
- Elevating HDL-C through CETPi represents a potential therapeutic strategy for IBD.
- Further research into CETPi for IBD therapy is warranted.
Abstract:
The anti-inflammatory and vasoprotective properties of HDL-C make it best known in cardiovascular disease and sepsis. We aimed to investigate whether interventions that target HDL-C metabolism may be used for the prevention and treatment of inflammatory bowel disease (IBD). The relationship between serum lipids and IBD clinical manifestations were analyzed in both respective and prospective cohort. Later, therapeutic effect and mechanism of cholesteryl ester transfer protein inhibitors (CETPis) in IBD treatment were explored by in vivo experiments. IBD patients had significantly reduced HDL-C, which was negatively correlated with their inflammatory status. Furthermore, HDL-C level was elevated by biologics agents and HDL-C concentration pretreatment was predictive for IBD patients' future disease severity. Elevating HDL-C by CETPi before or even after the onset of experimental colitis reduced disease severity, which is associated with an ATF3-dependent anti-inflammatory reprogramming of macrophages and with enhanced gut barrier function. Together, these results demonstrate an important role of HDL-C in IBD and indicate the potential pharmacological effects of CETPi for future IBD therapy through elevation of HDL-C.
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