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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Related Experiment Video

Updated: Sep 19, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's

Antonio Martín-Bastida1,2, María Cruz Rodríguez-Oroz1,2,3

  • 1Neurology and Neurosciences Department, Clínica Universidad de Navarra, Pamplona, Spain.

Journal of Movement Disorders
|June 8, 2025
PubMed
Summary

This review summarizes recent functional magnetic resonance imaging (fMRI) studies in Parkinson's disease (PD) longitudinal cohorts. It highlights multimodal approaches combining fMRI with biomarkers for tracking disease progression and monitoring therapies.

Keywords:
Cognitive and motor declineFunctional magnetic resonance imagingParkinson’s diseasePositron emission tomographyResting-state networks

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Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Functional magnetic resonance imaging (fMRI) is a key tool for studying Parkinson's disease (PD) pathophysiology.
  • Longitudinal studies tracking PD progression using fMRI are limited.

Purpose of the Study:

  • To review recent advances in functional fMRI studies within prospective Parkinson's disease cohorts.
  • To explore the integration of fMRI with other biomarkers for tracking PD progression.
  • To assess the potential of multimodal longitudinal functional approaches for understanding PD and monitoring interventions.

Main Methods:

  • Literature review of recent functional fMRI studies in prospective Parkinson's disease cohorts.
  • Analysis of studies combining fMRI with other biomarkers.
  • Focus on longitudinal and multimodal approaches.

Main Results:

  • Limited number of longitudinal fMRI studies exist for Parkinson's disease.
  • Emerging evidence supports multimodal approaches for tracking PD progression.
  • Functional imaging combined with biomarkers shows promise for monitoring disease course.

Conclusions:

  • Multimodal longitudinal functional imaging holds significant potential for understanding Parkinson's disease progression.
  • This approach can aid in monitoring the effectiveness of future therapeutic interventions.
  • Further research in this area is crucial for advancing PD management.