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Global trends in sitosterolemia research: A bibliometric and visualization analysis
Hui Wu1, Yinfei Xu1, Rong Cheng1
1Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China (Wu, Xu, Cheng, and Dr Chen).
This bibliometric analysis reveals key research trends in sitosterolemia, a rare lipid disorder. Genetic research, particularly focusing on phytosterols and lipid metabolism, remains a central theme in understanding this condition.
Area of Science:
- Biochemistry
- Genetics
- Metabolic Disorders
Background:
- Sitosterolemia is a rare genetic disorder of lipid metabolism.
- Characterized by elevated plant sterols, it causes xanthomatosis, atherosclerosis, and arthritis.
- Recent scholarly attention highlights the need for systematic research understanding.
Purpose of the Study:
- To systematically analyze the research status and development trends in sitosterolemia.
- To identify historical features, evolving topics, and emerging trends in the field.
- To provide insights for future research directions.
Main Methods:
- Bibliometric analysis of publications from Web of Science Core Collection and PubMed.
- Utilized CiteSpace software and Microsoft Excel for data analysis.
- Included 416 publications from 1974 to 2024.
Main Results:
- Publication and citation counts show fluctuating trends.
- Top institutions include University of Bonn and University of Texas System.
- Research hotspots focus on phytosterols, whole exome sequencing, and lipid metabolism.
- Keywords: sitosterolemia, humans, dietary-cholesterol, cholesterol, absorption.
- Genetic research is a significant and ongoing area.
Conclusions:
- Bibliometric findings offer a current overview of sitosterolemia research.
- Helps researchers identify hot topics and potential new research avenues.
- Emphasizes the foundational role of genetic mutations in sitosterolemia pathogenesis.
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