Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary restriction during active cancer therapy is associated with improved treatment response: a systematic review and meta-analysis.

Cancer biology & medicine·2026
Same author

Introducing the Blood-Tear Barrier: Structure, Function, and Disruption in Ocular Surface Homeostasis.

Progress in retinal and eye research·2026
Same author

Which features best differentiate Sjögren's-related from non-Sjögren's-related dry eye disease?

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Investigation Into the Collection and Isolation Workflows of Extracellular Vesicles From Tears.

Journal of extracellular biology·2026
Same author

Aptamers in Ocular Disease Therapy and Drug Delivery: Current Progress and Future Opportunities.

Current therapeutic research, clinical and experimental·2026
Same author

Tear fluid cortisol as a marker of acute stress reactivity: A validation study against salivary measures.

Psychoneuroendocrinology·2026

Related Experiment Video

Updated: Jan 6, 2026

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
09:22

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles

Published on: October 13, 2017

12.2K

International reporting guidelines for tear fluid research: A Delphi consensus.

Jente Schmeetz1, Nienke van de Sande1, William Rojas-Carabali2

  • 1University Eye Clinic Maastricht, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association
|June 8, 2025
PubMed
Summary

New guidelines standardize tear fluid research reporting to improve biomarker discovery and clinical applications. These international consensus-based recommendations enhance transparency and reproducibility in tear fluid studies.

Keywords:
BiomarkersDelphi methodReporting guidelinesReproducibilityTear fluidTransparency

More Related Videos

Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research
09:04

Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research

Published on: July 19, 2024

2.3K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.1K

Related Experiment Videos

Last Updated: Jan 6, 2026

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
09:22

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles

Published on: October 13, 2017

12.2K
Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research
09:04

Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research

Published on: July 19, 2024

2.3K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.1K

Area of Science:

  • Biomarker discovery and analysis
  • Ophthalmology and vision science
  • Proteomics and metabolomics

Background:

  • Tear fluid is a valuable, minimally invasive source for diagnostic biomarkers.
  • Lack of standardized reporting in tear fluid research hinders reproducibility.
  • Need for international consensus on reporting guidelines.

Purpose of the Study:

  • Establish international consensus-based reporting guidelines for tear fluid research.
  • Improve standardization, transparency, and reproducibility in the field.
  • Facilitate biomarker discovery and clinical applications.

Main Methods:

  • Utilized the Delphi methodology with 74 international professionals.
  • Evaluated 35 proposed reporting statements covering key research aspects.
  • Achieved consensus based on a 5-point Likert scale and ≥70% agreement.

Main Results:

  • Consensus reached on 34 of 35 statements in the first round.
  • 26 statements achieved strong consensus (≥90% agreement).
  • Developed detailed recommendations for standardized tear fluid study reporting.

Conclusions:

  • The TEAR-reporting guidelines (TEAR-RG) standardize tear fluid research practices.
  • Guidelines enhance reproducibility and transparency in this evolving field.
  • Standardized frameworks are crucial for advancing tear fluid biomarker research.