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  1. Home
  2. Epidemiologic And Survival Analysis For Patients With Secondary Esophageal Cancer: A Population-based Study And External Validation.
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  2. Epidemiologic And Survival Analysis For Patients With Secondary Esophageal Cancer: A Population-based Study And External Validation.

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Epidemiologic and survival analysis for patients with secondary esophageal Cancer: a population-based study and

Jie Wang1, Jingyun Zha2, Xiaoliang Dong1

  • 1Department of Cardiothoracic Surgery, The Third People's Hospital of Hefei/The Third Clinical College of Hefei, Anhui Medical University, Hefei, Anhui, China.

Expert Review of Anticancer Therapy
|June 9, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Secondary esophageal cancer (SEC) incidence is rising, with stage, age, and location impacting survival. A new prognostic model aids risk stratification for better treatment decisions.

Keywords:
EpidemiologySEEResophageal cancerprediction modelsurvival

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Area of Science:

  • Oncology
  • Epidemiology
  • Cancer Research

Background:

  • Limited research exists on the epidemiology, prognosis, and management of secondary esophageal cancer (SEC).
  • Understanding SEC trends and factors influencing patient outcomes is crucial for improving care.

Purpose of the Study:

  • To analyze the incidence trends of SEC using population-based data.
  • To identify significant prognostic factors for SEC survival.
  • To develop and validate a prognostic model for risk stratification in SEC patients.

Main Methods:

  • Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database and an external cohort.
  • Calculated incidence trends using Annual Percentage Change (APC).
  • Performed survival analysis using Cox regression models.

Main Results:

  • SEC incidence increased from 2000-2008, then stabilized.
  • Disease stage, age, and tumor location were significant prognostic factors (p < .05).
  • The developed prognostic model showed good predictive accuracy (C-index ≈ 0.73). Radiotherapy and chemotherapy improved survival, but not for early-stage or squamous cell carcinoma patients.

Conclusions:

  • A critical need exists for early detection and personalized treatment strategies for SEC.
  • The validated prognostic model can guide therapeutic decisions and enhance patient outcomes.