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  1. Home
  3. Prevalence Of Proteinuria In Dogs With Immune-mediated Disease.
  1. Home
  3. Prevalence Of Proteinuria In Dogs With Immune-mediated Disease.

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Prevalence of Proteinuria in Dogs With Immune-Mediated Disease.

James C Barton1, Alexander J German1, Erin M O'Connell1

  • 1Small Animal Teaching Hospital, The University of Liverpool, Liverpool, UK.

Journal of Veterinary Internal Medicine
|June 9, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Proteinuria is common in dogs with immune-mediated diseases, often presenting as severe cases. Screening for proteinuria is recommended for dogs with immune-mediated conditions.

Keywords:
autoimmunityglomerulopathyglucocorticoidspyrexiaurine protein–creatinine ratio (UPCR)

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Area of Science:

  • Veterinary Medicine
  • Immunology
  • Nephrology

Background:

  • Proteinuria is a known complication of autoimmune diseases in humans.
  • Limited veterinary literature exists on the association between proteinuria and immune-mediated diseases in dogs.

Purpose of the Study:

  • To investigate the prevalence and severity of renal proteinuria in dogs with primary immune-mediated diseases.
  • To identify clinical factors associated with proteinuria in these dogs.

Main Methods:

  • A retrospective, observational study of 144 dogs with primary immune-mediated diseases.
  • Data included signalment, clinical signs, urinalysis, and urine protein-creatinine ratio (UPCR).
  • Exclusion criteria prevented confounding factors like azotemia, hypoalbuminemia, or certain medications.

Main Results:

  • Proteinuria was present in 53% of dogs, with 26% exhibiting severe proteinuria.
  • Female dogs, those with pyrexia, or hemoglobinuria were significantly more likely to have proteinuria.
  • An association between steroid-responsive meningitis-arteritis and proteinuria magnitude was suggested.

Conclusions:

  • Proteinuria is a frequent and potentially severe finding in dogs with immune-mediated diseases.
  • Routine screening for proteinuria is advised as part of the diagnostic workup for these patients.