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  1. Home
  3. The Impact Of Naples Prognostic Score On Cognitive Impairment In Hemodialysis Patients: A Multicenter Study.
  1. Home
  3. The Impact Of Naples Prognostic Score On Cognitive Impairment In Hemodialysis Patients: A Multicenter Study.

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The impact of Naples prognostic score on cognitive impairment in hemodialysis patients: a multicenter study.

Yan Ran1,2, Yuqi Yang2, Yanzhe Peng2

  • 1Zunyi Medical University, Zunyi, China.

Renal Failure
|June 9, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

The Naples Prognostic Score (NPS) is linked to cognitive impairment (CI) in hemodialysis (HD) patients. Higher NPS indicates a greater risk of CI and dementia in this population.

Keywords:
Naples prognostic score (NPS)cognitive impairment (CI)dementiahemodialysis

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Area of Science:

  • Nephrology
  • Neurology
  • Geriatrics

Background:

  • Malnutrition and inflammation are common in hemodialysis (HD) patients, contributing to cognitive impairment (CI).
  • The Naples Prognostic Score (NPS) integrates nutritional and inflammatory markers.

Purpose of the Study:

  • To investigate the association between the Naples Prognostic Score (NPS) and the risk of cognitive impairment (CI) in patients undergoing hemodialysis.

Main Methods:

  • Recruited 2,725 HD patients and calculated NPS based on albumin, total cholesterol, lymphocytes, neutrophils, and monocytes.
  • Assessed cognitive function using the Mini-Mental State Examination (MMSE) score.
  • Employed logistic regression and interactive analyses to evaluate associations.

Main Results:

  • A significant positive association was found between NPS and CI risk (OR=1.120, p=0.009) and dementia risk (OR=1.153, p=0.010).
  • Higher NPS correlated negatively with MMSE scores (β=-0.178, p=0.015).
  • The association was more pronounced in younger patients (<65 years), those without diabetes, and without cerebrovascular disease (CVD).

Conclusions:

  • The Naples Prognostic Score (NPS) is positively associated with cognitive impairment (CI) in hemodialysis patients.
  • A dose-response relationship exists between NPS and CI risk.
  • NPS serves as a valuable indicator for assessing cognitive decline in HD patients.