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A Protocol for Transcranial Photobiomodulation Therapy in Mice

A Protocol for Transcranial Photobiomodulation Therapy in Mice

Published on: November 18, 2018

Transcranial Photobiomodulation Improves Cognitive Function, Post-Concussion, and PTSD Symptoms in Mild Traumatic

Tsz-Lok Lee¹, David Yuen-Chung Chan², Danny Tat-Ming Chan²

¹Department of Psychology, The Chinese University of Hong Kong, Hong Kong SAR, China.

Journal of Neurotrauma

|June 9, 2025

Summary

Transcranial photobiomodulation (tPBM) significantly improved cognitive function, sleep, and reduced symptoms like headaches and PTSD in mild traumatic brain injury (mTBI) patients. This non-invasive therapy shows promise for mTBI recovery.

Keywords:

cognitive function photobiomodulation post-concussion symptoms post-traumatic stress disorder sleep traumatic brain injury

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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Area of Science:

Neuroscience
Rehabilitation Medicine
Biomedical Engineering

Background:

Mild traumatic brain injury (mTBI) affects millions globally, often leading to persistent cognitive deficits, headaches, sleep disturbances, and PTSD.
Current treatments for mTBI sequelae are limited, highlighting the need for effective interventions.

Purpose of the Study:

To investigate the efficacy of transcranial photobiomodulation (tPBM) in improving cognitive deficits and associated symptoms in patients with mTBI.
To assess tPBM's impact on visual working memory, verbal learning, sleep quality, post-concussion symptoms, pain, and PTSD.

Main Methods:

A randomized, placebo-controlled, crossover trial involving 17 mTBI patients.
Participants received both real and sham tPBM, with assessments including neuropsychological tests, functional near-infrared spectroscopy (fNIRS), and self-rated questionnaires.
Interventions were administered in a counterbalanced order with a 1-week washout period.

Main Results:

Real tPBM significantly improved visual working memory, verbal learning, subjective sleep quality, and reduced physical post-concussion symptoms, pain intensity, and PTSD symptoms compared to baseline.
No significant improvements were observed with sham tPBM.
Observed improvements met the minimal clinically important difference, indicating clinical significance.

Conclusions:

Transcranial photobiomodulation (tPBM) is a safe and non-invasive intervention that can effectively improve cognitive deficits and associated symptoms in mTBI patients.
tPBM demonstrates potential as a rehabilitation strategy for enhancing recovery in TBI patients.
Further research is warranted to explore tPBM's role in TBI rehabilitation.