Related Experiment Video
Updated: Jun 12, 2025
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Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
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Differing Sensitivity of Antibodies Against IgG1 Explains the Discrepancy in the Detection of IgG1: A Validation
Satoru Kudose1, Nicholas J Steers2, Pouneh Dokouhaki3
1Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Kidney International Reports
|June 9, 2025
Abstract
No abstract available in PubMed .
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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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