Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.0K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lactate as a biomarker for discriminating and assessing prognosis of neonatal necrotising enterocolitis: A systematic review and meta-analysis.

Pakistan journal of medical sciences·2026
Same author

Study on the Synergistic Mechanism of Zwitterionic Surfactants and Nano-SiO<sub>2</sub> Particles in Oil Displacement.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Trends, disparities, and socioeconomic inequalities in periconceptional folic acid supplementation in China: a nationwide survey analysis.

BMC pregnancy and childbirth·2026
Same author

Point defect-driven switching of conductivity type in Bi<sub>2</sub>Te<sub>3</sub> films prepared by atomic layer deposition.

Nanoscale·2026
Same author

Ion-triggered reconfigurable hydrogels with salt-enhanced mechanical and swelling properties via network topological adaptation.

Nature communications·2026
Same author

Biodegradable and biocompatible poly(lactic acid) optical fibers for fiber-guided photothermal therapy of breast cancer cells in vitro.

Biomedical optics express·2026

Related Experiment Video

Updated: Jun 12, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.4K

Hotspots and frontiers of the relationship between gastric cancer and cancer-associated fibroblasts: a bibliometric

Xiangcheng Hu1, Lingling Ren1, Shuyuan Zhu1

  • 1Digestive Endoscopy Center, The Second People's Hospital of Lishui, Lishui, China.

Frontiers in Oncology
|June 9, 2025
PubMed
Summary
This summary is machine-generated.

This bibliometric analysis maps research on Cancer-Associated Fibroblasts (CAFs) and Gastric Cancer (GC) from 2003-2023. It identifies key trends, influential institutions, and future research directions in this critical area of oncology.

Keywords:
bibliometricscancer-associated fibroblastsgastric cancerhot spottumor microenvironment

More Related Videos

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
10:26

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Published on: October 21, 2022

1.9K
Three-dimensional Co-culture Model for Tumor-stromal Interaction
08:39

Three-dimensional Co-culture Model for Tumor-stromal Interaction

Published on: February 2, 2015

17.3K

Related Experiment Videos

Last Updated: Jun 12, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.4K
Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
10:26

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Published on: October 21, 2022

1.9K
Three-dimensional Co-culture Model for Tumor-stromal Interaction
08:39

Three-dimensional Co-culture Model for Tumor-stromal Interaction

Published on: February 2, 2015

17.3K

Area of Science:

  • Oncology
  • Cancer Research
  • Tumor Microenvironment

Background:

  • Cancer-Associated Fibroblasts (CAFs) are key components of the tumor microenvironment (TME).
  • A significant association exists between Gastric Cancer (GC) and CAFs.
  • Comprehensive data on GC and CAF research trends are limited.

Purpose of the Study:

  • To provide a panoramic overview of the research landscape concerning CAFs and GC.
  • To identify prominent research areas and influential contributors.
  • To anticipate future research trajectories and offer strategic recommendations.

Main Methods:

  • Bibliometric analysis of 1170 articles from the Web of Science Core Collection (2003-2023).
  • Utilized VOSviewer, CiteSpace, R software, and Microsoft Excel for analysis and visualization.
  • Examined publication trends, geographical contributions, key institutions, authors, and journals.

Main Results:

  • Publication surge observed from 2011-2023, with China as the leading contributor.
  • Identified key institutions (e.g., Osaka City University) and highly cited authors.
  • FRONTIERS IN ONCOLOGY and ONCOGENE are prominent journals in this field.
  • Key research foci include CAF impact on GC proliferation, angiogenesis, invasion, metastasis, EMT, immunosuppression, drug resistance, and their interplay.

Conclusions:

  • This bibliometric study offers a comprehensive view of CAF and GC research from 2003-2023.
  • Highlights key research themes and anticipates future directions.
  • Provides valuable insights and strategic recommendations for future research endeavors.