Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antihypertensive Drugs: Direct Renin Inhibitors

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bioluminescent xenograft model of acute myeloid leukemia for immunotherapy preclinical studies.

Leukemia research·2026

Same author

Complexes of Zinc(II) Chloride with <i>N</i>-Vinyl-, <i>N</i>-Allyl- and <i>N</i>-Propargylimidazoles: Structural, Theoretical and Biological Studies.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Zinc Signaling in Acute Kidney Injury.

Cells·2026

Same author

BDNF/TrkB Signaling in the Brain-Kidney Axis Under Functional Stress.

Biology·2026

Same author

Different Diagnoses, Common Ancestry: 22q11.2 Deletion Syndrome and Wiskott-Aldrich Syndrome in the Same Family.

Molecular syndromology·2026

Same author

Interleukin-6 in Natural and Pathophysiological Kidney Aging.

Cells·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2025

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Targeting interleukin-1 signaling for renoprotection.

Daria Bogdanova^1,2, Mikhail Y Samsonov³, Svetlana Lebedeva⁴

¹Division of Immunobiology and Biomedicine, Sirius University of Science and Technology, Sochi, Russia.

Frontiers in Immunology

|June 9, 2025

Summary

Interleukin-1 (IL-1) signaling drives kidney inflammation and damage. Targeting IL-1 pathways offers potential therapeutic strategies for various kidney diseases beyond autoimmune conditions.

Keywords:

ADPKD (autosomal dominant polycystic kidney disease)acute kidney injury chronic kidney disease cytokines interleukins nephroprotection

More Related Videos

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

Related Experiment Videos

Last Updated: Jun 12, 2025

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

Area of Science:

Nephrology
Immunology
Inflammation Biology

Background:

Sterile inflammation and immune-mediated damage are key in acute and chronic kidney diseases.
Interleukin-1 (IL-1) signaling, particularly IL-1α and IL-1β, initiates and amplifies renal inflammation.
Endogenous IL-1 antagonists regulate IL-1 signaling, but imbalances contribute to kidney fibrosis.

Purpose of the Study:

To review the role of IL-1 signaling in nephrology.
To explore potential therapeutic applications of IL-1 inhibitors in kidney diseases.
To analyze niches for IL-1 targeting in managing renal pathologies.

Main Methods:

Literature review of studies on IL-1 signaling in kidney disease.
Analysis of IL-1 pathway components and their role in renal pathophysiology.
Evaluation of current and potential therapeutic strategies involving IL-1 inhibition.

Main Results:

IL-1 signaling is a critical mediator in sterile kidney inflammation and fibrosis.
IL-1 inhibitors are effective in autoimmune-related renal complications.
Broader applications of IL-1 inhibition in diverse kidney diseases are anticipated.

Conclusions:

Dysregulated IL-1 signaling contributes significantly to kidney disease progression.
Targeting IL-1 represents a promising therapeutic avenue for a wider range of nephrological conditions.
Further research into IL-1 modulation could unlock new treatments for kidney fibrosis and damage.