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Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients

Lotte Keikes1, Marit S van Sandwijk2, Evert-Jan Kooi3

  • 1Amsterdam University Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Meibergdreef, 1105, AZ, Amsterdam, Netherlands.

Medical Mycology Case Reports
|June 9, 2025
PubMed

Insights

Medicopsis romeroi causes phaeohyphomycosis, a fungal infection mainly affecting immunocompromised patients. This case series presents treatment recommendations for extensive skin lesions caused by this rare mold.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Medicopsis romeroi is a rare brown-pigmented mold.
  • It causes phaeohyphomycosis, a fungal infection affecting skin and soft tissues.
  • Immunocompromised individuals are primarily affected and may develop disseminated disease.

Purpose of the Study:

  • To describe clinical presentations of M. romeroi infections.
  • To provide clinical practice recommendations for managing extensive skin lesions.
  • To highlight treatment challenges for phaeohyphomycosis.

Main Methods:

  • Case series describing two immunocompromised patients.
  • Review of clinical presentations and treatment outcomes.
  • Formulation of evidence-based treatment recommendations.

Main Results:

  • Two immunocompromised patients presented with extensive, persistent skin lesions due to M. romeroi.
  • Surgical excision combined with long-term antifungal therapy was the management approach.
  • Treatment outcomes and clinical course were documented.

Conclusions:

  • M. romeroi infections require a multidisciplinary approach.
  • Surgical intervention and prolonged antifungal therapy are crucial.
  • Further research is needed to establish definitive treatment guidelines.
Keywords:
Dematiaceous fungiFungal infectionImmunocompromised patientsMedicopsis romeroiPhaeohyphomycosisSolid organ transplant recipients

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