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Causal relationship between physical activity, sleep duration, sedentary behavior, and hypertension: A Mendelian
Chunmei Wang1, Jianting Zeng2, Hongduan Liu3
1Department of Medical Oncology, Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba District, Chongqing 400030, China.
American Journal of Preventive Cardiology
|June 9, 2025
Summary
Watching too much television is linked to higher hypertension risk. This Mendelian randomization study found that increased TV time may elevate blood pressure, with body mass index and waist-hip ratio acting as mediators.
Area of Science:
- Cardiovascular Disease Epidemiology
- Genetic Epidemiology
- Lifestyle Medicine
Background:
- Lifestyle behaviors are crucial for hypertension prevention.
- The causal links between physical activity, sleep, sedentary habits, and hypertension require clarification.
- Mendelian randomization (MR) analysis is a powerful tool to investigate these causal relationships.
Purpose of the Study:
- To investigate the causal associations between specific lifestyle behaviors and hypertension.
- To examine the roles of body mass index (BMI) and waist-hip ratio (WHR) as potential mediators.
- To assess the influence of confounding factors like smoking and education.
Main Methods:
- Utilized single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for sedentary behaviors, sleep duration, and physical activity.
- Employed inverse-variance weighting (IVW), weighted median, and MR-Egger regression for MR analysis.
- Conducted multivariate MR and mediation analyses using data from the FinnGen Biobank.
Main Results:
- Increased television viewing time showed a significant association with elevated hypertension risk (OR: 1.831).
- This association remained after adjusting for smoking but not for education level.
- BMI and WHR were identified as mediators in the relationship between television viewing and hypertension.
Conclusions:
- Increased time spent watching television is a potential risk factor for hypertension.
- Public health strategies should consider reducing sedentary screen time to mitigate hypertension risk.
- Further research is needed to explore the complex interplay of lifestyle, genetics, and hypertension.
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