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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Prognostic Significance of lncRNA ATB and SNHG16 Expression Levels in Patients with Hepatocellular Carcinoma.

Sahar Ravanshad1, Mohammadhossein Taherynejad2, Zohre Gerami1

  • 1Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Iranian Journal of Pathology
|June 9, 2025
PubMed
Summary

This study found that while ATB long noncoding RNA (lncRNA) was overexpressed in liver cancer tissues, neither ATB nor SNHG16 lncRNAs correlated with patient survival or clinicopathological features.

Keywords:
Hepatocellular CarcinomaLong Noncoding RNAsTumor

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators in biological processes.
  • Several lncRNAs have demonstrated oncogenic roles in various cancers.
  • Hepatocellular carcinoma (HCC) remains a significant global health challenge.

Purpose of the Study:

  • To investigate the expression patterns of ATB and SNHG16 lncRNAs in hepatocellular carcinoma.
  • To determine the prognostic value of ATB and SNHG16 in HCC patients.
  • To explore the association between lncRNA expression and clinicopathological features in HCC.

Main Methods:

  • Real-time quantitative PCR was utilized to measure ATB and SNHG16 expression in tumor and adjacent normal tissues.
  • Patients were stratified into high and low expression groups for each lncRNA.
  • Statistical analysis using SPSS version 22 assessed correlations with clinicopathological features and survival.

Main Results:

  • ATB lncRNA exhibited significantly higher expression levels in tumor tissues compared to adjacent normal tissues.
  • Overexpression of ATB was not found to be associated with any specific clinicopathological features of HCC.
  • No significant correlation was observed between the expression levels of ATB or SNHG16 and the survival rate of HCC patients.

Conclusions:

  • The study concludes that neither ATB nor SNHG16 overexpression is linked to survival outcomes in hepatocellular carcinoma.
  • The findings suggest that ATB and SNHG16 may not serve as reliable prognostic biomarkers for HCC based on current analysis.
  • Further research is warranted to fully elucidate the role of these lncRNAs in hepatocarcinogenesis.