Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

901
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
901
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

2.4K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
2.4K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

345
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
345
Cardiac Action Potential01:30

Cardiac Action Potential

1.1K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.1K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.2K
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

919
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
919

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polygenic risk modulates myocardial repolarization and T-wave geometry in congenital long-QT syndrome type 1: evidence from digital ECG phenotyping.

Frontiers in cardiovascular medicine·2026
Same author

A MATLAB Algorithm to Automatically Estimate the QT Interval and Other ECG Parameters and Validation Using a Machine Learning Approach in Congenital Long-QT Syndrome.

Journal of cardiovascular translational research·2025
Same author

Long QT syndrome in children and adolescents: risk factors and outcomes in a large German cohort.

European heart journal·2025
Same author

Mapping CD4+ T cell diversity in CSF to identify endophenotypes of multiple sclerosis.

Brain communications·2025
Same author

Generation of human induced pluripotent stem cell (hiPSC) lines (UKMi009-A and UKMi011-A) harboring a homozygous and heterozygous HCN4 variant from a family with inherited sinus node dysfunction (SND).

Stem cell research·2025
Same author

Unusual hypertrophic cardiomyopathy: case report of an early onset wild-type ATTR amyloidosis accompanied by a chromosomal duplication involving the <i>MYH6</i> and <i>MYH7</i> gene.

Frontiers in cardiovascular medicine·2025

Related Experiment Video

Updated: Jun 15, 2025

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

9.8K

Cardiac arrhythmias and genetics - current stage.

Schulze-Bahr1, Sven Dittmann1, Janis Kerkering1

  • 1Institute for Genetics of Heart Diseases (IfGH) University Hospital Münster (UKM) Albert-Schweitzer-Campus 1 (Gebäude D3) 48149 Münster Germany.

Medizinische Genetik : Mitteilungsblatt Des Berufsverbandes Medizinische Genetik E.V
|June 9, 2025
PubMed
Summary

Cardiogenetics focuses on inherited cardiac arrhythmias, rare primary electrical heart disorders. Genotyping aids early recognition and prevention of life-threatening events in these ion channel disorders.

Keywords:
Cardiac ion channel disordersCardiogeneticsInherited cardiac arrhythmiasLong-QT syndromeSCDSudden cardiac death

More Related Videos

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.1K

Related Experiment Videos

Last Updated: Jun 15, 2025

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

9.8K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.1K

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Molecular Biology

Background:

  • Inherited cardiac arrhythmias are rare primary electrical heart disorders.
  • Diagnosis relies on ECG with normal cardiac imaging.
  • Genetic basis is heterogeneous with incomplete variant detection rates.

Purpose of the Study:

  • To review genetic aspects of cardiac ion channel disorders.
  • To highlight the value of genotyping in diagnosis and prevention.
  • To discuss clinical modifiers and environmental triggers.

Main Methods:

  • Review of current literature and guidelines.
  • Focus on genetic basis of primary electrical heart disorders.
  • Discussion of diagnostic and preventative strategies.

Main Results:

  • Genetic basis involves cardiac ion channel genes.
  • Variant detection rates vary widely (10-80%).
  • Clinical expressivity is modulated by genetic and non-genetic factors.

Conclusions:

  • Genotyping is valuable for early disease recognition and diagnosis.
  • Understanding genetic and environmental factors is crucial for prevention.
  • Further research into polygenic risk scores is ongoing.