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Mechanistic Insights on Skin ageing and Dermatologic Interventions to Slow Ageing Process

Rajashree Sriram1, V Gopal1

  • 1From the Department of Pharmacognosy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry, India.

Indian Journal of Dermatology
|June 9, 2025
PubMed

Insights

Skin aging results from intrinsic and extrinsic factors, causing wrinkles and sagging. This review explores skin aging mechanisms and treatments, including procedures and energy-based devices.

Area of Science:

  • Dermatology and Gerontology
  • Molecular Biology and Biochemistry

Background:

  • Skin aging is influenced by intrinsic (chronological) and extrinsic (environmental) factors.
  • These factors induce morphological and physiological changes, leading to visible signs like wrinkles and sagging.
  • Key molecular similarities in skin aging include reactive oxygen species and matrix metalloproteinases induction.

Purpose of the Study:

  • To elucidate the mechanisms underlying skin aging.
  • To review current management strategies for dermatologic aging.
  • To discuss emerging trends in invasive procedures and energy-based devices for skin aging.

Main Methods:

  • Literature review focusing on skin aging.
  • Analysis of intrinsic and extrinsic aging factors.
  • Examination of molecular pathways involved in skin aging.
  • Review of therapeutic interventions for skin aging phenotypes.

Main Results:

  • Intrinsic and extrinsic factors synergistically drive skin aging.
  • Common aging phenotypes include coarseness, wrinkling, hyperpigmentation, telangiectasia, and sagging.
  • Reactive oxygen species and matrix metalloproteinases are key molecular mediators.
  • Various treatments, including invasive procedures and energy-based devices, are employed to address aging signs.

Conclusions:

  • Understanding skin aging mechanisms is crucial for effective management.
  • A combination of intrinsic and extrinsic factors contributes to skin aging.
  • Current and emerging treatments aim to mitigate the visible effects of skin aging.
Keywords:
Extrinsic ageingintrinsicmolecular mechanismtreatment strategies

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