Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Availability of insulin from parenteral nutrient solutions.

S S Weber, W A Wood, E A Jackson

    American Journal of Hospital Pharmacy
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patient-reported treatment toxicity and adverse events in Black and White women receiving chemotherapy for early breast cancer.

    Breast cancer research and treatment·2021
    Same author

    Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes

    Current oncology (Toronto, Ont.)·2020
    Same author

    Correction to: Measuring and understanding adherence in a home-based exercise intervention during chemotherapy for early breast cancer.

    Breast cancer research and treatment·2018
    Same author

    Measuring and understanding adherence in a home-based exercise intervention during chemotherapy for early breast cancer.

    Breast cancer research and treatment·2017
    Same author

    Patient perspectives on physical function after allogeneic hematopoietic stem cell transplantation: a qualitative study.

    Bone marrow transplantation·2017
    Same author

    Lower risk for cardiovascular mortality for patients with root filled teeth in a Finnish population.

    International endodontic journal·2017

    Significant insulin loss occurs in parenteral nutrition solutions, with factors like filters and PVC bags exacerbating the issue. Albumin and vitamins can help reduce this loss.

    Area of Science:

    • Biochemistry
    • Clinical Nutrition
    • Pharmaceutical Sciences

    Background:

    • Parenteral nutrition (PN) is crucial for patients unable to consume food orally.
    • Insulin is often added to PN to manage hyperglycemia, but its stability and delivery can be compromised.
    • Understanding factors affecting insulin loss is vital for optimizing PN therapy.

    Purpose of the Study:

    • To investigate the extent of insulin loss from total parenteral nutrient (TPN) solutions.
    • To identify key variables influencing insulin adsorption and degradation within PN admixtures.
    • To provide data for improving insulin delivery efficacy in TPN.

    Main Methods:

    • I125-tagged insulin was added to various TPN solutions.
    • Simulated clinical infusion conditions were used to prepare and drain solutions.

    Related Experiment Videos

  • Radioactivity measurements quantified the percentage of insulin remaining in infusion containers.

    • Main Results:

    • Basic amino acid solutions lost 44-47% of added insulin.
    • Inline filters and polyvinyl chloride (PVC) bags significantly increased insulin loss.
    • Insulin concentration had a minor but significant effect on loss.
    • Albumin and electrolytes/vitamins addition reduced insulin loss.

    Conclusions:

    • Substantial insulin loss occurs in TPN solutions, impacting therapeutic efficacy.
    • Material interactions (filters, PVC) and formulation components significantly influence insulin stability.
    • Strategies like adding albumin or vitamins may mitigate insulin loss in TPN.