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Updated: Jun 12, 2025

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Oral Bacterial Lysate OM-85 Prevents Respiratory Tract Infections in Asthma: The OMRIA RWE Study

Maria Elpida Christopoulou1,2, Lilia S Panteli1, John A Moisidis1

  • 1Asthma Clinics, Primary Care Clinics for Asthma, Allergy & Respiratory Health Athens, Patras, Kalavryta, Greece.

Journal of Asthma and Allergy
|June 9, 2025
PubMed
Abstract

Insights

OM-85 significantly reduced respiratory infections, asthma exacerbations, and healthcare visits in allergic asthma patients. This bacterial lysate improved symptom severity and reduced medication use in real-world settings.

Area of Science:

  • Immunology
  • Pulmonology
  • Pharmacology

Background:

  • OM-85 is a bacterial lysate known for antiviral effects and immune modulation.
  • Its role as an add-on therapy for allergic asthma requires real-world validation.

Purpose of the Study:

  • To evaluate the effectiveness of OM-85 as an add-on therapy in adults with moderate to severe allergic asthma.

Main Methods:

  • Retrospective cohort study of 137 adult allergic asthma patients over 12 months.
  • Comparison between standard of care (SoC) alone and SoC + OM-85.
  • Analysis of symptom episodes (CEPs), asthma exacerbations, healthcare utilization, and symptom severity (mSI) using propensity score weighting.

Main Results:

  • OM-85 group showed significant reductions: 60% fewer CEPs, 71% fewer exacerbations, 72% fewer unscheduled visits, 73% fewer oral corticosteroid courses, and 67% fewer antibiotic cycles.
  • Mean severity index (mSI) was 1.15 points lower in the OM-85 group (p < 0.001).

Conclusions:

  • OM-85 as an add-on therapy significantly reduced respiratory infection episodes and asthma exacerbations.
  • It also decreased healthcare utilization and lowered symptom severity in allergic asthma patients.
Keywords:
HRVOM-85allergic asthmaasthma exacerbationsbacterial lysateshuman rhinovirus (HRV)immunomodulation

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