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Updated: Jun 12, 2025

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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
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Using mobile technology to increase adherence to sublingual immunotherapy: Real-world study with a new app/web
Matheus Fonseca Aarestrup1, Akinori Cardozo Nagato2, Paula Fonseca Aarestrup3
1Allergy and Immunology Department - Hospital Maternidade Therezinha de Jesus - HMTJ, Juiz de Fora, MG, Brazil.
The World Allergy Organization Journal
|June 9, 2025
Summary
A mobile app significantly improved adherence to sublingual immunotherapy (SLIT) for allergic diseases. AllergyVax® enhanced patient engagement and reduced treatment dropout rates, showcasing digital tools
Area of Science:
- Immunology
- Digital Health
- Allergy Research
Background:
- Allergen immunotherapy (AIT) is crucial for allergic rhinitis and asthma, targeting type 2 inflammation.
- Patient-centered care (PCC) strategies are vital for improving treatment engagement.
- Sublingual immunotherapy (SLIT) adherence is often challenging.
Purpose of the Study:
- To evaluate the efficacy of the AllergyVax® mobile application in enhancing patient adherence to SLIT.
- To assess the impact of a digital tool on patient engagement and treatment outcomes in respiratory allergic diseases.
- To determine if a patient-centered digital approach improves SLIT completion rates.
Main Methods:
- Retrospective cross-sectional analysis of 482 patients undergoing SLIT for respiratory allergies.
- Comparison between a group using the AllergyVax® app (Group B) and a control group receiving standard information (Group A).
- The app provided reminders, symptom questionnaires, and facilitated patient-provider communication.
Main Results:
- SLIT adherence was significantly higher in the app group (92.11%) compared to the non-app group (46.32%).
- App users were 2.42 times more likely to maintain adherence and experienced an 82% reduction in dropout rates.
- The AllergyVax® app demonstrated consistent adherence improvement across diverse demographic groups.
Conclusions:
- Mobile applications like AllergyVax® are effective in promoting adherence to SLIT for allergic diseases.
- Integrating digital solutions into AIT enhances patient engagement and improves overall treatment outcomes.
- Innovative digital tools play a critical role in managing allergic diseases and supporting long-term patient adherence.
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