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A Case Series Examining the 1-year Follow-up Outcomes of Myocarditis Associated with COVID-19 Vaccination

Mohammed Thamer Ali1, Ammar Chapra1, Samah F A Mohamed2,3

  • 1Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.

Heart Views : the Official Journal of the Gulf Heart Association
|June 9, 2025
PubMed

Insights

Myocarditis following COVID-19 mRNA vaccination is rare, affecting young males within a week of vaccination. Most patients show favorable short-term recovery with minimal long-term consequences, though extended follow-up is recommended.

Area of Science:

  • Cardiology
  • Vaccinology
  • Public Health

Background:

  • COVID-19 mRNA vaccines have been associated with rare cases of myocarditis.
  • This condition primarily affects young males, typically presenting symptoms within one week post-vaccination.

Purpose of the Study:

  • To evaluate the long-term outcomes of individuals diagnosed with myocarditis after receiving COVID-19 vaccination.
  • To understand the potential long-term implications of vaccine-related myocarditis.

Main Methods:

  • A case series analysis was conducted.
  • Seventeen patients diagnosed with inflammatory myocarditis following COVID-19 mRNA vaccination were included.

Main Results:

  • Symptom onset occurred 24-96 hours post-vaccination.
  • Most patients experienced favorable short-term recovery with minimal long-term consequences.
  • Cardiac magnetic resonance imaging (CMR) revealed preserved ejection fraction and absence or minimal fibrosis in most patients, with one case showing hypertrophic cardiomyopathy-like fibrosis.

Conclusions:

  • While COVID-19 mRNA vaccine-related myocarditis appears to have a generally benign short-term course, prolonged clinical and CMR follow-up exceeding one year is essential.
  • Extended monitoring is crucial for a comprehensive understanding of the condition's true nature and long-term implications.
  • This approach will enhance the ongoing assessment of COVID-19 vaccination program safety and efficacy.
Abstract

Keywords:
COVID-19 vaccinemyocarditissevere acute respiratory syndrome coronavirus 2

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