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Updated: Sep 19, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Evaluating Trends In Rumination Syndrome: A Retrospective Analysis.

Shivangini Duggal1, Misbah Jilani2, Richard W McCallum3

  • 1Department of Internal Medicine, Texas Tech University, El Paso, TX, USA.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|June 9, 2025
PubMed
Summary
This summary is machine-generated.

Rumination syndrome treatment is effective with jejunostomy tubes (J-tubes) for nutritional support. Patients with J-tubes showed significant symptom improvement and weight gain, enhancing long-term management.

Keywords:
Rumination syndromefunctional gastrointestinal disordersjejunostomy tube

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Area of Science:

  • Gastroenterology
  • Functional Gastrointestinal Disorders
  • Digestive Health

Background:

  • Rumination syndrome is a functional gastrointestinal disorder characterized by effortless regurgitation after meals.
  • Diagnosis relies on Rome IV criteria, excluding structural abnormalities, and is confirmed by high-resolution manometry.
  • Treatment typically involves behavioral and medical therapies.

Purpose of the Study:

  • To evaluate the epidemiology, symptom profiles, diagnosis time, and treatment outcomes for rumination syndrome.
  • To specifically assess the impact of jejunostomy tube (J-tube) placement on nutritional support and symptom improvement.
  • To analyze the effectiveness of combined treatment approaches, including J-tube use.

Main Methods:

  • Retrospective cohort study of 133 patients with rumination syndrome at Texas Tech University Gastroenterology Clinic (July 2016 - February 2024).
  • Data collected on patient demographics, BMI, J-tube placement, duration, weight changes, and symptom improvement.
  • Statistical analyses performed using STATA, with significance set at p < 0.05.

Main Results:

  • 23 out of 133 patients required jejunostomy tube (J-tube) placement.
  • J-tube patients had lower initial BMI (21.07 vs 28.13) but experienced significantly greater weight gain and symptom improvement (100% vs 48.18%).
  • Average J-tube duration was 16 weeks, with an average weight gain of 38.8 pounds.

Conclusions:

  • Combined treatment approaches, especially with jejunostomy tubes, are highly effective for rumination syndrome management.
  • Jejunostomy tubes facilitate nutritional support, weight stabilization, and symptom control, improving treatment adherence.
  • This strategy enhances long-term quality of life for patients with rumination syndrome requiring nutritional intervention.