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Related Concept Videos

Loose Connective Tissue01:26

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Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
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Related Experiment Video

Updated: Jun 12, 2025

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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The interplay between white adipose tissue, adipokines, and structural gray matter changes.

Liana Okudzhava1,2, Stephanie Schulz1,2, Violetta Pilorz2,3

  • 1Department of Neurology, University of Lübeck, Lübeck, Germany.

Human Brain Mapping
|June 9, 2025
PubMed
Summary

Elevated leptin levels are linked to reduced gray matter volume in brain regions controlling appetite and decision-making. This study in males suggests a potential negative impact of high leptin on brain health and eating behaviors.

Keywords:
adipokinesgray matter volumeleave‐one‐out cross‐validationobesitywhite adipose tissue

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Radiology

Background:

  • Global obesity is a growing concern with significant health implications.
  • Obesity is associated with alterations in brain gray matter (GM) volume.
  • Adipokines, signaling molecules from fat tissue, may influence brain health.

Purpose of the Study:

  • To investigate the relationship between body fat compartments, adipokine levels, and GM volume variations in males.
  • To explore the interplay between adiposity, brain structure, and metabolic signals.

Main Methods:

  • Whole-body MRI and MR spectroscopy to assess adipose tissue and liver fat.
  • Measurement of leptin and adiponectin concentrations.
  • Structural brain imaging with cortical and subcortical segmentation for GM analysis.
  • Predictive modeling using leave-one-out cross-validation.

Main Results:

  • Diminished GM volume and thickness correlated with elevated leptin levels in brain areas regulating appetite, decision-making, and cognitive control (e.g., anterior insula, orbitofrontal cortex).
  • No significant relationship was found between GM volume and measured fat compartments.
  • Findings suggest a potential adverse effect of high leptin on brain health and eating habits.

Conclusions:

  • Heightened leptin concentrations may negatively impact brain structure and function related to eating behaviors.
  • Further research is needed to clarify the complex relationships between obesity, adipokines, and brain structure.