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Related Experiment Videos

Recent advances in X-ray microanalysis in dermatology.

B Forslind, T G Grundin, M Lindberg

    Scanning Electron Microscopy
    |January 1, 1985
    PubMed
    Summary

    Electron and proton microprobe X-ray analysis reveal trace element distribution in human hair and skin. These techniques identified non-homogeneous distribution of elements like calcium, iron, and zinc in hair, and element gradients in epidermis.

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    Clinical and experimental dermatology·2021

    Area of Science:

    • Dermatological research
    • Trace element analysis
    • Microscopy techniques

    Background:

    • Electron microprobe and proton microprobe X-ray analysis offer valuable insights into dermatological research.
    • Understanding trace element distribution is crucial for diagnosing and treating skin conditions.

    Purpose of the Study:

    • To investigate the distribution of trace elements in human hair and epidermis using electron and proton microprobe X-ray analysis.
    • To explore the relationship between epidermal water content and element distribution.
    • To examine elemental changes associated with proliferative skin reactions and conditions like atopic eczema and psoriasis.

    Main Methods:

    • Utilized electron microprobe analysis (EMPA) on freeze-dried cryosections and freeze-substituted skin sections.
    • Employed proton microprobe analysis (PMPA) for trace element determination in human hair and epidermis.
    • Investigated elemental distribution of Na, P, K, Ca, Fe, Zn, Ni, and Cr.
    • Assessed water content differences using Br-doped resin in freeze-substituted skin.

    Main Results:

    • Demonstrated non-homogeneous distribution of Ca, Fe, and Zn in human hair, unlike homogeneously distributed sulfur.
    • Observed distinct gradients of Na, P, and K across the stratum granulosum in human epidermis, influenced by water content.
    • Found no significant water content differences in the stratum corneum of atopic eczema patients compared to normal skin.
    • Correlated increased P and K levels with proliferative epidermal reactions in both experimental models and psoriatic plaques.

    Conclusions:

    • Electron and proton microprobe X-ray analysis are effective tools for dermatological trace element research.
    • Epidermal element distribution is influenced by water content, with gradients observed in the stratum granulosum.
    • Elemental analysis can help elucidate the pathophysiology of proliferative skin conditions.

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