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Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD)
Behrooz Darbani1, Thorsten Brodersen2, Anette Liljensøe3
1Molecular Diagnostics and Clinical Research Unit, Department of Internal Medicine, University Hospital of Southern Denmark, Aabenraa, Denmark. bds@rsyd.dk.
Insights
The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort supports genetic research for Crohn's disease and ulcerative colitis. This large cohort provides valuable data for improving inflammatory bowel disease management.
Area of Science:
- Genetics and epidemiology of chronic inflammatory diseases.
Background:
- Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, presents a significant public health challenge.
- Genetic factors play a crucial role in the pathogenesis of IBD.
- Large, well-characterized cohorts are essential for advancing IBD research.
Purpose of the Study:
- To describe the Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort.
- To highlight the cohort's utility for genetic research in IBD.
- To underscore the potential for improving IBD management and patient outcomes.
Main Methods:
- The CHB-CID: IBD cohort comprises 327,084 genotyped individuals, with 10,626 diagnosed with IBD as of May 2023.
- Includes patients with IBD, individuals without IBD, and healthy blood donors as controls.
- Clinical data is systematically collected from Danish registries and patient records, covering demographics, diagnoses, comorbidities, medications, and procedures.
Main Results:
- The cohort represents Danish adults (>18 years) with validated IBD diagnoses.
- Features extensive population coverage and continuous recruitment with regular data updates.
- Provides a robust dataset for genetic association studies and epidemiological research in IBD.
Conclusions:
- The CHB-CID: IBD cohort is a valuable resource for genetic and clinical research into inflammatory bowel disease.
- Its comprehensive data and large scale facilitate deeper understanding of IBD.
- Aims to enhance IBD management strategies and improve patient quality of life.
Abstract:
The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes both patients without IBD and healthy blood donors as control groups. Clinical data is collected from Danish registries and patient records, including details on hospital contacts, co-morbidities, medication, surgical procedures, and laboratory investigations. The cohort features a wide age range (> 18 years), extensive population coverage representative of Danish adults, and validated IBD diagnoses. Finally, the cohort benefits from continuous recruitment and regular updates of clinical information. The aim is to enhance IBD management and ultimately improve patients' quality of life.
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