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Role of Rs228648 and Rs2890565 single nucleotide polymorphisms in Urotensin-2 gene in prostate cancer.

Fatma Sertgoz1, Ozgur Efiloglu2, Emrah Nikerel1

  • 1Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.

Molecular Biology Reports
|June 9, 2025
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Summary

This study found no association between Urotensin II gene polymorphisms (rs2890565 and rs228648) and prostate cancer (PCa) risk or progression in the Turkish population. Further research is needed to clarify the role of these genetic variations in PCa development.

Keywords:
Prostate cancerUrotensin-IIrs228648 polymorphismrs2890565 polymorphism

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Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Urotensin-II (U-II), a peptide hormone, is implicated in breast cancer due to its mitogenic and angiogenic effects.
  • Single nucleotide polymorphisms (SNPs) in the Urotensin II (UTS2) gene, specifically rs2890565 and rs228648, have been linked to breast cancer.
  • The association of these UTS2 gene polymorphisms with prostate cancer (PCa) risk and metastasis remains largely unexplored.

Purpose of the Study:

  • To investigate the association between UTS2 gene polymorphisms (rs2890565 and rs228648) and prostate cancer (PCa) susceptibility.
  • To evaluate the correlation of these polymorphisms with PCa progression, including Gleason score, tumor stage, and metastasis.
  • To determine the role of UTS2 gene variants in the development and advancement of PCa in the Turkish population.

Main Methods:

  • Genotyping of 141 healthy controls and 158 PCa patients using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • Confirmation of genotyping results through Sanger sequencing.
  • Statistical analysis of genotype distributions under dominant and recessive genetic models.

Main Results:

  • No statistically significant association was observed between UTS2 gene rs2890565 or rs228648 polymorphisms and the risk of developing PCa.
  • These polymorphisms were not significantly correlated with Gleason score, tumor stage, or metastatic stage in PCa patients.
  • Genotype frequencies were uniformly distributed between PCa patients and healthy volunteers in the studied Turkish population.

Conclusions:

  • The UTS2 gene polymorphisms rs2890565 and rs228648 are not associated with PCa susceptibility or progression in the Turkish population.
  • The findings suggest that these specific genetic variations do not play a significant role in the development or advancement of prostate cancer in this cohort.
  • Further studies with larger and diverse populations may be warranted to definitively establish or refute the link between UTS2 gene polymorphisms and PCa.