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Adenosine spares platelets during cardiopulmonary bypass in man without causing systemic vasodilatation
Scandinavian Journal of Thoracic and Cardiovascular Surgery
|January 1, 1985
Summary
Adenosine infusion during cardiopulmonary bypass (CPB) helps preserve platelet count. This cardiac surgery technique showed no significant adverse effects on blood pressure or blood loss.
Area of Science:
- Cardiovascular Surgery
- Pharmacology
- Hematology
Background:
- Cardiopulmonary bypass (CPB) can lead to platelet activation and consumption.
- Maintaining adequate platelet function is crucial during cardiac surgery.
- Adenosine is a nucleoside with potential cardioprotective and anti-inflammatory effects.
Purpose of the Study:
- To investigate the effect of adenosine infusion on platelet count during CPB.
- To assess the impact of adenosine on mean arterial blood pressure (MABP) during CPB.
- To evaluate the influence of adenosine on postoperative blood loss.
Main Methods:
- A prospective study involving 13 patients undergoing CPB with adenosine infusion and 12 control patients.
- Adenosine administered at 0.1 mg/kg/min, with venous and arterial adenosine levels monitored.
- Platelet count, MABP, and postoperative blood loss were measured and compared between groups.
Main Results:
- Adenosine infusion significantly increased venous adenosine concentrations while maintaining low arterial levels.
- Platelet count was significantly higher in the adenosine group during and shortly after CPB compared to controls.
- No significant intergroup differences were observed in postoperative blood loss or major vasodilation; fewer controls required vasodilator treatment.
Conclusions:
- Adenosine infusion during CPB in humans effectively spares platelets.
- Adenosine administration during CPB does not cause significant adverse hemodynamic effects.
- Adenosine represents a potential therapeutic agent for preserving platelet function during cardiac surgery.