Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro
Xiaomei Zhang1, Weidong Qiang2, Yongxin Guo1
1School of Pharmacy, Jilin Medical University, Jilin, People's Republic of China.
Objectives:
Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging. Renal aging is one of the main triggers of CDK. Therefore, many researchers in the field are looking for natural, green and healthy anti-renal-aging bioactive molecules.
Methods And Results:
Western-blot, ELISA and indirect immunofluorescence were performed to evaluate the biological activity of fucoxanthin against renal aging in vitro and in vivo models. First, in the in vitro model, we evaluated the effect of fucoxanthin on renal cell senescence. We found that fucoxanthin could alleviate the kidney cell senescence caused by H2O2 by detecting a series of senescence markers. In the in vivo model, the experimental results showed that fucoxanthin could alleviate the aging of the kidney by Sa-β-gal staining and detection of aging-related marker molecules. Furthermore, we also found that fucoxanthin could alleviate kidney fibrosis.
Conclusions:
In this study, our results showed that fucoxanthin was able to alleviate renal aging in vivo and in vitro models, suggesting that fucoxanthin could be a functional food to treat and relieve kidney aging.
Insights
Fucoxanthin effectively alleviates kidney aging in both laboratory and living models. This natural compound shows promise as a functional food for combating age-related kidney decline and fibrosis.
Area of Science:
- Gerontology
- Nephrology
- Nutraceuticals
Background:
- Global populations are aging, increasing the prevalence of age-related diseases.
- Kidney function naturally declines with age, a process termed renal aging.
- Renal aging is a primary risk factor for chronic kidney diseases (CKD).
Purpose of the Study:
- To investigate the anti-aging effects of fucoxanthin on kidney cells and tissues.
- To evaluate fucoxanthin's potential as a natural intervention for renal aging.
Main Methods:
- *In vitro* studies using cell models to assess senescence markers.
- *In vivo* studies in animal models to evaluate kidney aging and fibrosis.
- Techniques included Western blot, ELISA, indirect immunofluorescence, and Sa-β-gal staining.
Main Results:
- Fucoxanthin demonstrated a significant ability to alleviate kidney cell senescence induced by hydrogen peroxide *in vitro*.
- Fucoxanthin treatment reduced kidney aging markers and Sa-β-gal staining *in vivo*.
- The compound also showed efficacy in mitigating kidney fibrosis.
Conclusions:
- Fucoxanthin effectively ameliorates renal aging in both *in vitro* and *in vivo* experimental systems.
- These findings suggest fucoxanthin's potential as a functional food ingredient for managing kidney aging.
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