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Sleep and circadian parameters in Behçet's syndrome: a comparative analysis using actigraphy and questionnaires
Alessandro Colitta1, Simone Bruno2,3, Francy Cruz-Sanabria4
1Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Rheumatology (Oxford, England)
|June 9, 2025
Summary
Behçet syndrome (BS) patients with active disease or fibromyalgia experience poor sleep quality and fragmented sleep. All BS patients show increased obstructive sleep apnoea syndrome (OSAS) risk, warranting screening.
Area of Science:
- Rheumatology
- Sleep Medicine
- Chronobiology
Background:
- Sleep disturbances are common in Behçet syndrome (BS), often linked to active disease and fibromyalgia.
- Sleep impairments in BS patients without these comorbidities, along with obstructive sleep apnoea syndrome (OSAS) risk and circadian preferences, are under-researched.
Purpose of the Study:
- To compare sleep and circadian parameters in BS patients (with/without active disease/fibromyalgia) versus healthy controls (HCs).
- To investigate OSAS risk and circadian rhythm preferences in BS patients.
Main Methods:
- Cross-sectional study involving 45 BS patients and 61 matched HCs.
- Objective (actigraphy) and subjective (questionnaires) assessments of sleep and circadian parameters.
- Clinical evaluation of disease activity and fibromyalgia; regression models for predictors.
Main Results:
- BS patients with active disease and/or fibromyalgia had poorer sleep quality and higher sleep fragmentation than other groups.
- No significant sleep or circadian differences were found between BS patients without active disease/fibromyalgia and HCs.
- All BS patients exhibited a higher OSAS risk compared to HCs.
Conclusions:
- Active Behçet syndrome and fibromyalgia correlate with sleep and circadian rhythm disturbances.
- Screening for sleep/circadian issues is recommended for BS patients with active disease or fibromyalgia.
- OSAS screening is advised for all BS patients experiencing sleep disturbances.
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