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Roadmap for a generally accepted model to predict first hepatic decompensation in compensated advanced chronic liver

Mattias Mandorfer1,2,3, Mathias Jachs1,2,3, Georg Semmler1,2,3

  • 1Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Hepatology (Baltimore, Md.)
|June 9, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
ascitescirrhosisportal hypertensionvariceal bleedingvarices

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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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