Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Management of Insomnia

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...

Insomnia

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Digitally delivered cognitive bias modification for interpretation targeting hostile interpretation bias in compulsory drug rehabilitation: A feasibility randomized trial.

Psychiatry research·2026

Same author

Improvement of PTSD symptoms via mobile app-delivered acceptance-commitment therapy intervention: A task-state functional magnetic resonance imaging randomized controlled trial.

Psychological trauma : theory, research, practice and policy·2026

Same author

Anxiety development trajectories in junior high students: effects of family functioning and gender, and prediction of non-suicidal self-injury.

BMC psychology·2026

Same author

Corrigendum to "Exploring emotion regulation in PTSD with Insomnia: A task-based fMRI study" [J. Psychiatr. Res. 189 (2025) 125-137].

Journal of psychiatric research·2025

Same author

Corrigendum to "Exploring emotion regulation in PTSD with Insomnia: A task-based fMRI study"[J. Psychiatr. Res. 189 (2025) 125-137].

Journal of psychiatric research·2025

Same author

Trauma Timing and Its Impact on Brain Activation During Flexible Emotion Regulation in PTSD: Insights From Functional MRI.

Human brain mapping·2025

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Exploring emotion regulation in PTSD with Insomnia: A task-based fMRI study.

Yuyi Zhang¹, Yunxiao Guo¹, Xiaoqin Wang²

¹Key Laboratory of Adolescent Cyberpsychology and Behavior (Ministry of Education), School of Psychology, Central China Normal University, Wuhan, Hubei, 430012, China; Key Laboratory of Human Development and Mental Health of Hubei Province, National Intelligent Society Governance Experiment Base (Education), School of Psychology, Central China Normal University, Wuhan, Hubei, 430012, China.

Journal of Psychiatric Research

|June 9, 2025

Summary

Post-traumatic stress disorder (PTSD) with insomnia shows distinct brain activity in emotion regulation areas compared to PTSD without insomnia. These neural differences may help identify biomarkers for PTSD and guide new treatments.

Keywords:

Emotion regulation PTSD Sleep disturbances fMRI

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Related Experiment Videos

Last Updated: Sep 19, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Area of Science:

Neuroscience
Psychiatry
Medical Imaging

Background:

Sleep disturbances and emotion dysregulation are key symptoms of post-traumatic stress disorder (PTSD).
Neural mechanisms linking PTSD and insomnia require further investigation.
This study examines brain activity during emotional processing in PTSD patients with and without insomnia.

Purpose of the Study:

To investigate the neural differences in emotion processing and regulation between PTSD patients with and without comorbid insomnia.
To identify potential neural biomarkers for PTSD with insomnia.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to study 46 PTSD patients (23 with insomnia, 23 without) and 28 controls.
Participants completed the Shifted Attention Emotion Appraisal Task (SEAT) during fMRI scans.
Whole-brain and region-of-interest (ROI) analyses compared neural activity.

Main Results:

PTSD patients with insomnia showed reduced activation in the left dorsolateral prefrontal cortex (BA46) and left inferior frontal gyrus (BA47) during implicit emotion processing.
Deactivation in the left inferior temporal gyrus (BA37) was observed during appraisal-based emotion regulation.
Insomnia severity correlated with activation in the left fusiform gyrus (BA37) in the PTSD-insomnia group.

Conclusions:

Identified distinct neural mechanisms in PTSD patients with comorbid insomnia.
Altered brain activity in specific regions may serve as biomarkers for PTSD with insomnia.
These findings suggest potential targets for novel therapeutic interventions.