Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

42
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
42
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

700
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
700
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

45
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
45
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

26
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
26
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

301
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
301

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Thyroid Hormone Levels and Thyroid Hormone Sensitivity with Adverse Clinical Outcomes in Euthyroid Patients with Ischemic Stroke.

Current neurovascular research·2026
Same author

Plasma choline and betaine and neurological function trajectory after acute ischemic stroke.

BMC neurology·2026
Same author

Mismatch-time ratio combined with ASPECTS: a novel indicator of favorable prognosis in multimodal ct prediction of anterior circulation large vessel occlusion.

BMC neurology·2026
Same author

Impacts of Remnant Cholesterol and Residual Inflammation on Clinical Outcomes After Ischemic Stroke.

JACC. Advances·2026
Same author

Multiple Cardiac Biomarkers and Long-Term Neurological Deficits Trajectory After Ischemic Stroke.

Journal of the American Heart Association·2026
Same author

Renal function and effect of early antihypertensive therapy in acute ischaemic stroke: a subgroup analysis of the CATIS-2 trial.

Stroke and vascular neurology·2026

Related Experiment Video

Updated: Sep 19, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K

Remnant cholesterol and post-stroke cognitive function: A multicenter prospective study.

Hong Li1, Zhengbao Zhu2, Mengyao Shi2

  • 1Department of Epidemiology, School of Public Health, Chongqing Medical University, Chongqing, China.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|June 9, 2025
PubMed
Summary
This summary is machine-generated.

Elevated remnant cholesterol (RC) levels were associated with a lower risk of post-stroke cognitive impairment (PSCI) after three months. This protective effect was more pronounced in individuals without overweight conditions.

Keywords:
Cognitive impairmentIschemic strokeRemnant cholesterol

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Related Experiment Videos

Last Updated: Sep 19, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Post-stroke cognitive impairment (PSCI) is a common complication following ischemic stroke.
  • Remnant cholesterol (RC), calculated as total cholesterol minus LDL-C and HDL-C, is an emerging cardiovascular risk factor.
  • The association between baseline RC levels and PSCI remains incompletely understood.

Purpose of the Study:

  • To investigate the relationship between baseline remnant cholesterol (RC) levels and the incidence of post-stroke cognitive impairment (PSCI) at three months post-stroke.
  • To determine if RC levels predict cognitive outcomes in patients who have experienced an acute ischemic stroke.

Main Methods:

  • Utilized data from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).
  • Calculated baseline remnant cholesterol (RC) levels using the formula: RC = TC - LDL-C - HDL-C.
  • Assessed cognitive function at three months using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
  • Employed binary logistic regression to analyze the association between RC tertiles and PSCI, adjusting for relevant covariates.

Main Results:

  • Included 523 participants in this prospective study.
  • The highest tertile of baseline RC was significantly associated with a reduced risk of PSCI compared to the lowest tertile (OR: 0.38; 95% CI: 0.23-0.63).
  • This association persisted after multivariable adjustment (OR: 0.40; 95% CI: 0.21-0.75).
  • In patients with BMI ≤ 24.9 kg/m², higher RC tertiles showed reduced PSCI risk (OR: 0.32 and 0.16), an effect not seen in those with BMI > 24.9 kg/m² (P for interaction = 0.036).

Conclusions:

  • Elevated baseline remnant cholesterol levels are linked to a decreased risk of developing post-stroke cognitive impairment at three months.
  • This protective association is particularly evident in ischemic stroke patients who are not overweight.
  • Remnant cholesterol may serve as a potential biomarker for cognitive outcomes post-stroke.