Related Experiment Video
Updated: Sep 19, 2025

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Assessing chest wall thickness sensitivity onin-vivolung counting efficiency in military-specific mesh-type
Yi Wei1, Wyatt W Smither2, Wesley E Bolch3
1Nuclear & Radiological Engineering and Medical Physics Programs, George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States of America.
Abstract:
In radiological and nuclear emergencies, military personnel and first responders are at elevated risk of internal contamination via inhalation of airborne radionuclides. Rapidin-vivoassessments are required for efficient triage, regulatory compliance, and medical intervention. This study investigates the impact of chest wall thickness (CWT) on lung counting efficiency using military-specific mesh-type human computational phantoms that represent the current standards and anthropomorphic parameters of U.S. members of the military. A 2″ × 2″ NaI(Tl) scintillation detector with digital base was modeled and benchmarked against experimental measurements using polymethyl methacrylate slab phantoms to assess attenuation effects. Monte Carlo simulations in Particle and Heavy Ion Transport code System were employed to characterize lung deposition of radionuclides, with variations in CWT examined across different anthropometric models. Results demonstrated an inverse exponential relationship between CWT and detector peak counting efficiency, with minor deviations in female phantoms due to geometric constraints. These results support improved calibration approaches forin-vivoradiation detection systems and enable more consistent internal contamination assessments across a range of body types during emergency response operations.

