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Related Experiment Video

Updated: Sep 19, 2025

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
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Risk Factors, Pathogenesis, Diagnosis, and Treatment Options for COVID-Associated Osteonecrosis: A Systematic Review.

Sean B Sequeira1, Lynne P Jones2, Stuart B Goodman3

  • 1Department of Orthopedic Surgery, Medstar Union Memorial Hospital, Baltimore, Maryland.

The Journal of Arthroplasty
|June 9, 2025
PubMed
Summary
This summary is machine-generated.

Osteonecrosis following COVID-19 infection is rare but requires awareness. This review details its presentation, causes, diagnosis, and treatment for orthopedic surgeons.

Keywords:
COVID-19MRIcorticosteroidsjoint-preserving proceduresosteonecrosis

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Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Pathophysiology

Background:

  • COVID-19 associated osteonecrosis is a rare but significant clinical entity.
  • Limited data exists on the characteristics of patients with this condition.
  • Understanding this condition is crucial given its incidence during the pandemic.

Purpose of the Study:

  • To systematically review and characterize COVID-19 associated osteonecrosis.
  • Identify clinical presentation and epidemiology.
  • Elucidate pathophysiology, diagnostic modalities, and treatment guidelines.

Main Methods:

  • Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Searched three databases for relevant literature.
  • Included 10 articles providing data on clinical aspects, pathophysiology, diagnosis, and treatment.

Main Results:

  • Variable time between COVID-19 infection and osteonecrosis onset.
  • Symptoms include joint pain and pain with weight-bearing, similar to standard osteonecrosis.
  • Corticosteroid use identified as a key risk factor.
  • Radiographs and MRI used for diagnosis.
  • Treatment ranged from conservative management to surgical interventions like joint replacement.

Conclusions:

  • Orthopaedic surgeons must be vigilant in screening for COVID-19 associated osteonecrosis.
  • Knowledge of clinical presentation, pathophysiology, diagnosis, and treatment is essential for patient management.
  • Appropriate screening and management strategies are vital for patients with a history of COVID-19.