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Published on: February 22, 2019

Impact of removing gentamicin from an antibiotic restriction program

G J Gorse, R B Belshe

    Southern Medical Journal
    |October 1, 1985
    PubMed

    Insights

    Removing gentamicin sulfate restrictions increased its use while decreasing tobramycin sulfate use. Total aminoglycoside procurement and patient care, including nephrotoxicity rates, remained unchanged, leading to lower pharmacy costs.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Health Economics

    Background:

    • Gentamicin sulfate and other aminoglycosides required infectious disease approval for prescribing.
    • Antibiotic stewardship programs often involve restrictions to optimize use and cost.

    Purpose of the Study:

    • To evaluate the impact of removing prescribing restrictions on gentamicin sulfate.
    • To assess changes in aminoglycoside usage, costs, and patient safety outcomes.

    Main Methods:

    • Retrospective analysis of antibiotic procurement data before and after decontrol.
    • Comparison of gentamicin and tobramycin sulfate usage patterns.
    • Evaluation of nephrotoxicity rates and prescribing indications.

    Main Results:

    • Gentamicin sulfate usage increased, while tobramycin sulfate usage decreased post-decontrol.
    • Total procurement of aminoglycosides did not significantly change.
    • No significant changes observed in indications, pretreatment evaluations, or nephrotoxicity rates.

    Conclusions:

    • Removing prescribing restrictions for gentamicin sulfate lowered pharmacy costs.
    • Decontrol did not negatively impact patient care or safety outcomes related to aminoglycoside use.

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