Related Experiment Video

Updated: Jun 13, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

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Published on: February 6, 2015

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Window-of-opportunity trials to screen effective agents and optimize dose in breast cancer prevention

G Aurilio1, D Serrano1, M Lazzeroni1

  • 1Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCCS, Milan, Italy.

NPJ Breast Cancer
|June 9, 2025
PubMed

Insights

Window-of-opportunity trials effectively screen breast cancer risk reduction agents. Low-dose tamoxifen showed success, and similar studies are underway with low-dose exemestane for breast cancer interception.

Area of Science:

  • Oncology
  • Clinical Trials
  • Pharmacology

Background:

  • Window-of-opportunity trials are crucial for evaluating breast cancer risk reduction strategies.
  • Identifying effective agents and optimal dosing is key for successful cancer interception.

Purpose of the Study:

  • To review the scientific evidence supporting window-of-opportunity trials in breast cancer risk reduction.
  • To assess the utility of these trials in screening agents and optimizing dose.

Main Methods:

  • Review of scientific literature on window-of-opportunity trials for breast cancer.
  • Analysis of past trials, including low-dose tamoxifen and ongoing exemestane studies.

Main Results:

  • Low-dose tamoxifen was successfully evaluated in a window-of-opportunity trial.
  • This agent was subsequently validated in a phase-III trial for breast cancer risk reduction.

Conclusions:

  • Window-of-opportunity trials are a valuable tool for breast cancer risk reduction research.
  • Further investigation into agents like low-dose exemestane is warranted for cancer interception.

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