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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
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Recent developments with pH-responsive lyotropic liquid crystalline lipid nanoparticles for targeted bioactive agent
Natinael Koyra1, Haitao Yu1, Calum J Drummond1
1School of Science, STEM College, RMIT University, Melbourne, Victoria, Australia.
Expert Opinion on Drug Delivery
|June 10, 2025
Summary
pH-responsive lipid nanoparticles (pR_LNPs) offer advanced delivery for bioactive agents. Ionizable lipids and self-assembly properties are key for enhancing mRNA therapeutics and overcoming biological barriers.
Area of Science:
- Nanotechnology and Biomaterials Science
- Drug Delivery Systems
- Biochemistry and Molecular Biology
Background:
- Lyotropic liquid crystalline lipid nanoparticles (LNPs) are versatile platforms for delivering bioactive agents, owing to their biomimetic nature and ability to encapsulate large molecules.
- The properties of LNPs are phase-dependent, influenced by factors like lipid composition and pH-responsiveness at the lipid-water interface.
- pH-responsive nanocarriers are crucial for targeted delivery, especially in the context of emerging mRNA therapeutics.
Purpose of the Study:
- To review recent advances in pH-responsive lipid nanoparticles (pR_LNPs) for bioactive agent delivery.
- To highlight the impact of ionizable lipids, copolymers, and drug molecules on the performance of pR_LNPs.
- To explore the interplay between self-assembly, interface ionization, and artificial intelligence in developing next-generation nanocarriers.
Main Methods:
- Literature review of recent scientific advances in pH-responsive lipid nanoparticles.
- Analysis of key concepts in LNP formation, self-assembly, and pH-responsiveness.
- Discussion of the role of ionizable lipids and copolymers in nanocarrier design.
Main Results:
- Ionizable lipids can be incorporated into nanocarriers to create pH-responsive systems.
- The self-assembly and interface ionization properties of LNPs significantly influence their efficacy.
- pR_LNPs show great promise for enhancing mRNA therapeutics delivery.
Conclusions:
- pH-responsive lipid nanoparticles are a rapidly advancing platform technology with significant potential in drug delivery.
- Further research integrating self-assembly, ionization, and AI could accelerate the development of novel mRNA therapeutics.
- The strategic incorporation of ionizable lipids and copolymers is essential for optimizing pR_LNP performance.
Keywords:
block polymerscubosomesdrug deliveryhexosomesionizable lipidslipid nanoparticleslyotropic liquid crystalspH-responsivenessMore Related Videos
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