Hyperdiploid myeloma: The silent majority

Hyperdiploid multiple myeloma (Hy-MM) is a common (50% of MM cases), but frequently under-recognized subtype of MM. Hy-MM is characterized by the presence of multiple trisomies of the odd numbered chromosomes (with the exception of chromosomes 13 and 17), leading to an average chromosome count of 53. Despite its prevalence, Hy-MM tends to receive less attention compared to high-risk subtypes. Thus, gaps in our understanding of Hy-MM remain underscoring the need for continued research ultimately to aid in targeted therapies and personalized treatment strategies to improve outcomes in this subgroup.