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3D Printed Bioelastomer Scaffold for Mandibular Defect Repair Based on Rapid Distraction Therapy
Yingjie Yan1, Byeong Seop Kim1, Xiaojun Chen1
1Plastic and reconstructive surgery, Shanghai Red Cross Ninth People's Hospital: Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, China.
Advanced Healthcare Materials
|June 10, 2025
Summary
This study introduces a 3D-printed scaffold for rapid mandibular distraction osteogenesis (MDO), accelerating bone healing in rabbit mandibles. This innovation promises improved clinical outcomes for mandibular defect repair.
Area of Science:
- Regenerative Medicine
- Biomaterials Engineering
- Craniofacial Surgery
Background:
- Mandibular distraction osteogenesis (MDO) is standard for mandibular hypoplasia but has limitations.
- Long distraction periods require frequent hospital visits.
- Shortened periods risk bone non-union and poor bone quality.
Purpose of the Study:
- To develop a rapid MDO technique using a 3D-printed scaffold for mandible defect repair.
- To evaluate the scaffold's ability to support bone regeneration and osseointegration.
- To overcome MDO limitations by shortening the distraction period.
Main Methods:
- A customized 3D-printed polyglycolic acid (PGS) scaffold was designed.
- The scaffold was loaded with bone marrow stromal cells (BMSCs).
- This was combined with a rapid MDO protocol in a rabbit mandible model.
Main Results:
- The PGS scaffold accommodated dynamic changes in the distraction gap.
- BMSCs-loaded scaffolds created a conducive osteogenic environment.
- The approach accelerated bone regeneration and osseointegration, shortening the distraction period.
Conclusions:
- 3D-printed PGS scaffolds combined with rapid MDO show potential for efficient mandibular defect repair.
- This method enhances bone regeneration and osseointegration.
- It offers a promising clinical advancement for large-scale mandibular reconstruction.
