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Design strategies for titanium surfaces to adsorb and release drugs: An in vitro study
Pablo Yael Carrazco Ávila1,2, Juan Ignacio Rosales Leal1, Miguel Ángel Rodríguez Valverde3
1Department of Stomatology (Prosthodontics Division), School of Dentistry, University of Granada, Campus de Cartuja s/n., Granada, 18071, Spain.
Background:
During the early postoperative period, it is important that the patient recovers without pain and inflammation, while preserving their quality of life. In this sense, coated titanium surfaces have been designed to release anti-inflammatory and analgesic drugs during the first postoperative hours.
Objective:
Evaluate the adsorption capacity and release profile of different bioactive titanium surfaces treated with three different drugs: acetaminophen, doxepin and ibuprofen.
Methods:
Four bioactive surfaces (polished, oxidized, hydroxyapatite precipitate, and polyvinyl alcohol coating surfaces) were physiochemically treated and analyzed.
Results:
Hydroxyapatite coatings were the roughest, while PVA coating was the softest. Acetaminophen was the only drug detected on all the surfaces. In contrast, higher drug doses were loaded into the PVA coatings, showing a satisfactory release profile.
Conclusion:
The results suggest that a rougher or ionically charged surface does not guarantee drug adsorption. In contrast, the use of a transport vehicle such as a polyvinyl coating ensures the release of the drug, initiating its therapeutic effect within the first minutes, and maintained for a period of between 120 and 180 min.
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