Indolent NK-Cell Lymphoproliferative Disorder of the Nasal Cavity: A Case Report and Review of the Literature
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Summary
This summary is machine-generated.This study reports the first case of indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract (iNKLPD) presenting as a nasal cavity lesion. This finding expands the known anatomical sites for iNKLPD and aids in understanding its clinical presentation.
Area Of Science
- Hematology
- Oncology
- Pathology
Background
- Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract (iNKLPD) is a newly recognized entity in the WHO Classification of Haematolymphoid Tumours.
- While primarily affecting the GI tract, iNKLPD has been reported in rare extra-intestinal sites.
Purpose Of The Study
- To document the first occurrence of iNKLPD in the nasal cavity.
- To contribute to the understanding of iNKLPD's pathological diagnosis and clinical management.
Main Methods
- Histopathological examination with hematoxylin-eosin staining and immunohistochemical profiling (CD56, CD3, BCL2, TIA1, granzyme B, Ki-67).
- In situ hybridization for Epstein-Barr virus (EBV)-encoded RNA and T-cell receptor (TCR) gene rearrangement analysis via PCR.
- Proteomics, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed.
Main Results
- A 67-year-old woman presented with a nasal mass, diagnosed as iNKLPD via immunohistochemistry and molecular analyses.
- The tumor showed positive expression for CD56, CD3, BCL2, TIA1, granzyme B, with a 50% Ki-67 index.
- EBV and TCR gene rearrangement were negative; no recurrence was observed after 11 months.
Conclusions
- This case represents the first documented iNKLPD lesion in the nasal cavity, expanding the disease's known manifestations.
- Proteomics and pathway analyses offer novel insights into the molecular mechanisms of this rare disorder.
- This finding enhances the comprehensive understanding of iNKLPD's pathological diagnosis and clinical management.
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